Daniel Hal Solomon, MD, MPH Associate Physician, Brigham and Women's Hospital Professor of Medicine, Harvard Medical School Brigham and Women's Hospital Department of Medicine Rheumatology, Immunology Boston, MA 02115

28 Jul Delays in Denosumab (Prolia®) Injections Linked to Increased Risk of Fractures

Posted at 09:58h in Annals Internal Medicine, Author Interviews, Brigham & Women's - Harvard, Osteoporosis by

MedicalResearch.com Interview with:

Daniel Hal Solomon, MD, MPH Associate Physician, Brigham and Women's Hospital Professor of Medicine, Harvard Medical School Brigham and Women's Hospital Department of Medicine Rheumatology, Immunology Boston, MA 02115

Dr. Solomon

Daniel Hal Solomon, MD, MPH
Associate Physician, Brigham and Women’s Hospital
Professor of Medicine, Harvard Medical School
Brigham and Women’s Hospital
Department of Medicine
Rheumatology, Immunology
Boston, MA 02115

Editor’s note: Prolia® is the trade name for denosumab. 

MedicalResearch.com: What is the background for this study?

Response: We conducted this study to assess whether delays in denosumab (injections were associated with an increased risk of fractures. In a prior study, we found that the improvements in bone mineral density were reduced among patients who delayed injections.

MedicalResearch.com: What are the main findings? 

Response: In the current study, we also found that delays in denosumab injections of > 4 months were associated with an increased risk of fractures, especially vertebral fractures.

MedicalResearch.com: What should readers take away from your report?

Response: Readers should understand that delays of over 4 months are associated with an increased risk of fracture, making on time injections more important. 

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: We are examining systems for improving on time injections. 

Disclosures: I have received grants from Amgen, unrelated to the present study. 

Citation

Delayed Denosumab Injections and Fracture Risk Among Patients With Osteoporosis
Houchen Lyu, Kazuki Yoshida, Sizheng S. Zhao, Jie Wei, Chao Zeng, Sara K. Tedeschi, Benjamin Z. Leder, Guanghua Lei, Peifu Tang, and Daniel H. Solomon

Annals of Internal Medicine 0 0:0

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Last Updated on July 28, 2020 by Marie Benz MD FAAD

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