01 May Elevated Kidney Biomarker Creatinine Predicts Worse Outcome in STEMI Heart Attack
MedicalResearch.com Interview with:
Mohamed Khayata, MD
Internal Medicine Resident PGY-3
Cleveland Clinic Akron General
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Previous studies showed that patients with ST-elevation myocardial infarction (STEMI) who had elevated creatinine and/or impaired creatinine clearance on presentation had higher short- and long-term mortality independent of other cardiovascular risk factors.
We used the National Cardiovascular Database Registry to investigate the impact of creatinine levels at the time of presentation on the cardiovascular outcomes in patients who presented with STEMI.
Our study showed that elevated creatinine levels correlated with higher incidence of atrial fibrillation, bleeding, heart failure, and cardiogenic shock during hospital stay after the percutaneous intervention.
MedicalResearch.com: What should readers take away from your report?
Response: Creatinine level is being checked in almost all patients who present with STEMI within few hours of presentation. Based on previous reports and our results, creatinine is a critical marker that correlate not only with mortality, but is also with morbidity during hospital stay. This marker should be used as a predictor of worse outcomes; thus, patients with higher creatinine levels should be provided higher attention.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Response: Based on our study limitations, I would encourage performing similar outcomes analysis in larger group, multi-center registries. I would also suggest extending outcomes to post-discharge status including quality of life besides cardiovascular complications.
MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.
Citation: Abstract presented at the 2017 National Kidney Foundation Spring Clinical Meeting
The Impact of Admission Serum Creatinine on Major Adverse Clinical Events in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
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Last Updated on May 1, 2017 by Marie Benz MD FAAD