Novel Models of Late-Onset Alzheimer’s Disease Based on GWAS

MedicalResearch.com Interview with:

Gregory Carter

Dr. Carter

Gregory Carter, PhD
Associate Professor at The Jackson Laboratory

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: Animal models for late-onset Alzheimer’s disease (LOAD) will be of significant benefit for the discovery and characterization of links between specific genetic factors and the molecular pathways associated with the disease. To date, most animal models have been based on rare, early-onset Alzheimer’s disease genes that incompletely capture the complexity of LOAD and have not translated well to therapies. Therefore, developing and utilizing animal models based on genes hypothesized to play a role in LOAD will provide new insights into its basic biological mechanisms. 

MedicalResearch.com: What should readers take away from your report?

Response: Previous research has identified risk genes for late-onset Alzheimer’s disease in the human population. By analyzing gene expression in mouse models with associated gene variants or mutations in addition to post-mortem human brains from AD patients, we found changes in gene expression in AD-related pathways. These results begin to provide a detailed map of the specifics effects produced by each risk gene and what molecular mechanisms underlie disease pathology. 

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: This is a pilot study that provides a platform for further exploration into the causes and progression of late-onset Alzheimer’s disease . Assessing animal models and different ages and/or with different combinations of  late-onset Alzheimer’s disease risk variants can provide novel insight for finding molecular targets and developing new drugs for Alzheimer’s disease.

No disclosures.

Citation AAIC 18 abstract

Whole-Exome Analysis of Late-Onset Alzheimer’s Disease Reveals Novel Candidate Genes Involved in Cognitive Function

Jul 27, 2018 @ 5:47 pm

The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.

 

Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.