11 Apr New Marker to Predict Recurrence of Hepatocellular Carcinoma
MedicalResearch.com Interview with:
Wei-ping Zhou, MD, PhD
Department of Hepatic Surgery
Eastern Hepatobiliary Surgery Hospital
MedicalResearch.com: What are the main findings of the study?
Answer: The main finding is that Quantitative HBsAg can be used as a new prognostic factor of Hepatocellular Carcinoma recurrence after partial hepatectomy in patients with a low HBV-DNA level.
MedicalResearch.com: Were any of the findings unexpected?
Answer: We are some surprised to our results. It is difficulty to find a good marker which actually reflects the status of HBV infection and predicts postoperative prognosis in HCC patients with a low HBV-DNA load. Previous study showed that HBsAg assay using a quantitative measure could indicate activity of HBV infection and high HBsAg level (HBsAg >1000 IU/ml) can be used as an independent risk factor of HCC development. Our results suggested that HBsAg level may be used to complement HBV-DNA level in predicting Hepatocellular Carcinoma recurrence, especially in patients with low HBV-DNA levels.
MedicalResearch.com: What should clinicians and patients take away from your report?
Answer: Our results suggested that low HBV-DNA did not represent inactivity and low HBsAg level maybe represent true inactivity. We should pay more attention to the Hepatocellular Carcinoma patients with low HBV-DNA level but high HBsAg level. There were still activity of in some of this patients. This patients should be under more close supervision.
Prediction of Hepatocellular Carcinoma Recurrence in Patients With Low Hepatitis B Virus DNA Levels and High Preoperative Hepatitis B Surface Antigen Levels
Huang G, Lau W, Zhou W, et al. Prediction of Hepatocellular Carcinoma Recurrence in Patients With Low Hepatitis B Virus DNA Levels and High Preoperative Hepatitis B Surface Antigen Levels. JAMA Surg. 2014;():. doi:10.1001/jamasurg.2013.4648.