MedicalResearch.com Interview with:
Guy Fagherazzi, MSc, PhD, HDR
Senior Research Scientist in Digital & Diabetes Epidemiology
Center of Research in Epidemiology and Population Health
Inserm, Paris-South Paris-Saclay University
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Migraine has further been associated with increased risk of overall and specific cardiovascular disease events.
Because migraine has also been associated with factors related with insulin resistance and type 2 diabetes, an association between migraine and diabetes has been hypothesized.
We observed a lower risk of type 2 diabetes in women with active migraine.
We also show a linear decrease of migraine prevalence long before and a plateau long after type 2 diabetes diagnosis.
MedicalResearch.com: What should readers take away from your report?
Response: Our results can have substantial implications regarding the understanding of mechanisms underlying these two conditions. Because plasma glucose concentration rises with time up to type 2 diabetes occurrence, the prevalence of migraine symptoms may decrease.
Consequently, tracking the evolution – and especially the decrease – of migraine frequency in migraineurs at high risk of diabetes, such as obese individuals, irrespectively of age, could be the sign of an emerging increased blood glucose levels, prediabetes or type 2 diabetes.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: Our results may suggest a potential role of both hyperglycemia and hyperinsulinism on migraine occurrence. This hypothesis deserves further investigation. A similar study in men should be conducted as well.
Fagherazzi G, El Fatouhi D, Fournier A, et al. Associations Between Migraine and Type 2 Diabetes in WomenFindings From the E3N Cohort Study. JAMA Neurol. Published online December 17, 2018. doi:10.1001/jamaneurol.2018.3960
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