MedicalResearch.com Interview with:
Hariom Yadav, PhD
Assistant Professor, Molecular Medicine
Comprehensive Cancer Center
Center on Diabetes, Obesity, and Metabolism
Redox Biology & Medicine Ctr
Sticht Center on Aging
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Currently, the use of probiotics is increasing for health benefits of consumers, however the source of probiotics available in the market remains scarcely known. According to scientific community and regulatory standpoint, human-origin probiotics are highly recommended. Hence, we isolated these probiotics from baby diapers, because infant microbiome carries large number of beneficial bacteria.
In addition, we optimized our probiotics to produce higher amount of short-chain fatty acids (SCFAs; beneficial metabolites produced by the gut microbiome), because the levels of SCFAs decreases in several human diseases like obesity, diabetes, cancer, autoimmune and inflammatory bowel diseases. Hence, our probiotics can be used to bring back SCFAs levels and may benefit people suffering from these diseases.
MedicalResearch.com: What should readers take away from your report?
Response: We think, this is one of its first kind study where probiotics isolated from human infant gut shown potential to increase SCFAs, and can be used to benefit human diseases like obesity, diabetes and autoimmune diseases.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: We expect that our newly isolated probiotics can be used for improving health of individuals those are suffering from diseases that are related to gut microbiome abnormalities, and reduced SCFAs. We are optimizing our probiotics to incorporate in several formulations, to conduct clinical studies and collaborate with industrial partners to bring into the market.
Ravinder Nagpal, Shaohua Wang, Shokouh Ahmadi, Joshua Hayes, Jason Gagliano, Sargurunathan Subashchandrabose, Dalane W. Kitzman, Thomas Becton, Russel Read, Hariom Yadav. Human-origin probiotic cocktail increases short-chain fatty acid production via modulation of mice and human gut microbiome. Scientific Reports, 2018; 8 (1) DOI: 10.1038/s41598-018-30114-4
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