26 Mar Psoriasis Patients At Higher Risk for Multiple Pathological Fractures

MedicalResearch.com Interview with:
Dr. Jonathan L. Silverberg MD PhD MPH
Assistant Professor in Dermatology
Medical Social Sciences and Preventive Medicine
Northwestern University, Chicago, Illinois

Dr. Jonathan Silverberg

Response: Psoriasis is associated with a number of potential risk factors for developing osteoporosis and pathological fractures, including including low vitamin D, chronic inflammation, higher rates of cigarette smoking and systemic corticosteroid usage. We hypothesized that adults with psoriasis have higher rates of osteoporosis and pathological fractures.

We examined data from the 2002-2012 National Inpatient Sample, which contains a representative 20% sample of all hospitalizations in the United States. We found that psoriasis was associated with higher odds of osteopenia, osteoporosis, osteomalacia, ankylosing spondylitis, and pathological fractures. In particular, psoriasis was associated with vertebral, pelvic, femoral and tibial/fibular fractures. The associations between psoriasis and pathological fractures were more pronounced in women than men.

MedicalResearch.com: What should clinicians and patients take away from your report?

Response: Patients with psoriasis appear to be at higher risk for multiple pathological fractures. These fractures contribute to increased morbidity, costs of care and potentially long-term mortality. Many of these fractures may be preventable with improved control of psoriasis and reduction of risk factors for fractures.

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Response: Further studies are needed to confirm these findings and determine the ideal approaches to prevention and treatment of these comorbidities.

MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.

Citation:

J Am Acad Dermatol. 2017 Mar 14. pii: S0190-9622(16)31163-X. doi: 10.1016/j.jaad.2016.11.046. [Epub ahead of print]
Association of psoriasis and psoriatic arthritis with osteoporosis and pathological fractures.
Kathuria P1, Gordon KB1, Silverberg JI2.

Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions.

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Last Updated on March 26, 2017 by Marie Benz MD FAAD