12 Apr Retevmo® (selpercatinib) Demonstrates Activity Against Advanced RET Fusion Positive Advanced Solid Tumors
MedicalResearch.com Interview with:
Dr. Subbiah
Vivek Subbiah, MD
Department of Investigational Cancer Therapeutics
Division of Cancer Medicine
The University of Texas MD Anderson Cancer Center
MedicalResearch.com: What is the background for this study?
Response: RET fusions occur predominantly in 2% of lung cancers and 10-20% of thyroid cancers, and in low frequency in an increasing number of diverse cancers, including pancreatic cancer, salivary gland cancer, and colorectal cancer. The therapeutic relevance of RET fusions occurring outside of lung and thyroid cancers has not been well established..
MedicalResearch.com: What are the main findings?
Response: Selpercatinib is a first-in-class highly selective and potent CNS-active RET kinase inhibitor and has received approval in multiple countries including the United States and Europe for the treatment of RET fusion-positive lung as well as RET-driven thyroid cancers. Selpercatinib demonstrates promising activity across a variety of non-lung and non-thyroid RET fusion positive advanced solid tumors, including treatment-refractory GI malignancies
MedicalResearch.com: What should readers take away from your report?
Response: RET fusions in tumors other than non-small cell lung cancer and thyroid cancer are uncommon but potentially actionable. The objective response rate by investigator’s assessment in this heavily pretreated patient population was 47% and included complete responses, and the efficacy was observed across cancer types and a spectrum of fusion partners.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: These analyses reiterate the importance of broad-based genomic profiling to identify actionable oncogenic drivers, including RET fusions.
Citation: AACR 2021 Abstract
Vivek Subbiah, Bhavana Konda, Todd Bauer, Caroline McCoach, Gerald Falchook, Masayuki Takeda, Jyoti Patel, Jared Weiss, Nir Peled, Lyudmila Bazhenova, Victoria Soldatenkova, Pearl French, Nora Drove, Oliver Gautschi, Alexander Drilon. MD Anderson Cancer Center, Houston, TX, The Ohio State University Comprehensive Cancer Center, Columbus, OH, Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville, TN, UCSF Helen Diller Comprehensive Cancer Center, San Francisco, CA, Sarah Cannon Research Institute at HealthONE, Denver, CO, Kindai University Hospital Faculty of Medicine, Osaka, Japan, Northwestern University Feinberg School of Medicine, Chicago, IL, University of North Carolina Chapel Hill, Chapel Hill, NC, Shaare Zedek Medical Center, Jerusalem, Israel, University of California San Diego, San Diego, CA, Eli Lilly and Company, Indianapolis, IN, University of Berne and Cantonal Hospital of Luzerne, Luzerne, Switzerland, Memorial Sloan Kettering Cancer Center, New York, NY
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Last Updated on April 12, 2021 by Marie Benz MD FAAD