"Blood Pressure Bulb Block Integrative Cancer Medical Center 12-2-14" by Steven Depolo is licensed under CC BY 2.0

RESPECT Study: Intensive Blood Pressure Control Better for Secondary Stroke Prevention

MedicalResearch.com Interview with:
"Blood Pressure Monitor" by Medisave UK is licensed under CC BY 2.0Kazuo Kitagawa, MD PhD

Department of Neurology
Tokyo Women’s Medical University
Tokyo, Japan

MedicalResearch.com: What is the background for this study? What are the main findings

Response:   Reduction in blood pressure (BP) reduces the rates of recurrent stroke, but the optimum BP target remained unclear.

The results of RESPECT Study together with up-dated meta-analysis showed the benefit of intensive blood pressure lowering (<130/80 mmHg) compared with standard BP lowering (<140/90 mmHg). 

MedicalResearch.com: What should readers take away from your report?

Response: The results of RESPECT Study gave us clear evidence of intensive blood pressure lowering for better prevention of secondary stroke.

Physicians need to manage blood pressure to less than 130/80 mmHg in patients with a history of stroke.

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: RESPECT Study excluded elderly patients over 85 years old, thus optimal blood pressure  target for secondary stroke prevention in elderly patients needs to be investigated.

Optimal blood pressure target needs to be investigated separately in patients with a history of infarction or hemorrhage.

The RESPECT study group was funded by Merck and Co. Inc, Bristol-Myers Squibb Company, Towa Pharmaceutical Co., Ltd, and Omron Corporation.


Kitagawa K, Yamamoto Y, Arima H, et al. Effect of Standard vs Intensive Blood Pressure Control on the Risk of Recurrent StrokeA Randomized Clinical Trial and Meta-analysisJAMA Neurol. Published online July 29, 2019. doi:10.1001/jamaneurol.2019.2167

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Last Updated on July 29, 2019 by Marie Benz MD FAAD