Author Interviews, Depression, Endocrinology, Nature / 27.08.2023
USC Study Finds Strong Correlation Between Estrogen-Reactive Hormones and Depressive States
MedicalResearch.com Interview with:
Huizhong Whit Tao, PhD
Professor of Physiology & Neuroscience
Zilkha Neurogenetic Institute
Department of Physiology & Neurosience
Keck School of Medicine
University of Southern California
MedicalResearch.com: What is the background for this study?
Response: Previously, we published a study in which we found that a group of neurons, namely glutamatergic neurons, in the medial preoptic area (MPOA) of the hypothalamus mediate stress-induced anxiety states. This result inspired us to explore whether the MPOA can play a more general role in mood regulation. Fluctuations in the productive hormones secreted by women’s ovaries are known to cause mood swings.
In some cases, rapid changes in the secretion of ovarian hormones can cause depressive-like symptoms. Key examples are postpartum and peri-menopausal depression. In this study, we intended to test whether the MPOA can also play a part in depressive states that are linked to fluctuations in ovarian hormones.
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