breast cancer Tag

03 Apr Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer

Posted at 00:39h in Author Interviews, Breast Cancer, Genetic Research, PNAS

MedicalResearch.com eInterview with Dr. Mathieu Lupien PhD

Dr. Mathieu Lupien PhD Princess Margaret Cancer Centre, University Health Network Ontario Cancer Institute (OCI) Assistant Professor Department of Medical Biophysics University of Toronto

Princess Margaret Cancer Centre, University Health Network Ontario Cancer Institute (OCI) Assistant Professor Department of Medical Biophysics University of Toronto MedicalResearch.com: What are the main findings of the study? Dr. Lupien: Approximately 50% of breast cancer patients fail to respond to the standard of care based on endocrine (hormonal) therapy. Our research identifies a mechanism that accounts for this resistance. Drugs against this mechanism are already tested for other diseases. Hence, our discovery should rapidly help reposition these drugs against endocrine therapy resistant breast cancer.

28 Mar Predictors of depression in breast cancer patients treated with radiation: Role of prior chemotherapy and nuclear factor kappa B

Posted at 13:40h in Author Interviews, Breast Cancer, Cancer Research, Depression, Mental Health Research

MedicalResearch.com Interview with Mylin A. Torres, M.D. Assistant Professor Department of Radiation Oncology Emory University School of Medicine Atlanta, GA 30322 MedicalResearch.com: What are the main findings of the study? Dr. Torres: Radiation treatment for breast cancer is not associated with increased depressive symptoms, but of disease and treatment-related factors, prior chemotherapy treatment is a significant predictor of depression before and after radiation treatment. Prior chemotherapy treatment was associated with inflammatory mediators, including nuclear factor-kappa B DNA binding, soluble tumor necrosis factor-alpha receptor 2, and interleukin-6, which predicted for depressive symptoms after radiation on univariate analysis.

13 Jan Breast Cancer News from Medical News Today

Posted at 13:04h in Breast Cancer, Cancer Research, Chemotherapy

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28 Mar Intensity Modulated Radiation Therapy Reduces Risk of Side Effects in Breast Cancer Patients

Posted at 22:41h in Breast Cancer, Cancer Research, Radiation Therapy

Newswise — Breast cancer patients treated with intensity modulated radiation therapy (IMRT) instead of standard whole breast irradiation (WBI) have a lower incidence of acute or chronic toxicities, according to a study in Practical Radiation Oncology (PRO), the official clinical practice journal of the American Society for Radiation Oncology (ASTRO). Researchers...

28 Mar Report: New More-Sensitive Blood Test Catches Recurring Breast Cancer a Year Earlier

Posted at 20:55h in Breast Cancer

Newswise — SAN DIEGO, March 28, 2012 Research was presented at a meeting of the American Chemical Society — A new blood test is twice as sensitive and can detect breast cancer recurrence a full year earlier than current blood tests, according to a scientist who reported here today at the...

15 Mar Dietary Cadmium May Be Linked with Breast Cancer Risk

Posted at 13:00h in Breast Cancer, Cancer Research, Toxin Research

Newswise — PHILADELPHIA — Dietary cadmium, a toxic metal widely dispersed in the environment and found in many farm fertilizers, may lead to an increased risk of breast cancer, according to a study published in Cancer Research, a journal of the American Association for Cancer Research. Cadmium occurs at low concentrations naturally,...

06 Jan Study: Moderate red wine drinking may help cut women’s breast cancer risk

Posted at 16:04h in Author Interviews, Breast Cancer

LOS ANGELES – Drinking red wine in moderation may reduce one of the risk factors for breast cancer, providing a natural weapon to combat a major cause of death among U.S. women, new research from Cedars-Sinai Medical Center shows. The study, published online in the Journal of Women's Health, challenges the...

08 Dec Risk for developing new cancer in other breast increased for survivors with BRCA mutation

Posted at 20:34h in Breast Cancer

SAN ANTONIO — Breast cancer survivors who carry the BRCA1 or BRCA2 genetic mutation are at high risk for developing contralateral breast cancer — a new primary tumor in the other breast — and certain women within this group of carriers are at an even greater risk based on age...

08 Dec Many women do not undergo breast reconstruction after mastectomy

Posted at 20:31h in Breast Cancer

SAN ANTONIO — Despite the benefits, only a small minority of women, regardless of age, are opting for immediate reconstructive breast surgery after undergoing mastectomy for treatment of breast cancer, according to data presented at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 6-10, 2011. Research has shown that...

20 Nov Researchers find genetic rearrangements driving 5 to 7 percent of breast cancers

Posted at 23:26h in Breast Cancer, Cancer Research, Duke, Genetic Research, Nature, University of Michigan

ANN ARBOR, Mich. — Researchers at the University of Michigan Comprehensive Cancer Center have discovered two cancer-spurring gene rearrangements that may trigger 5 to 7 percent of all breast cancers. These types of genetic recombinations have previously been linked to blood cancers and rare soft-tissue tumors, but are beginning to be...

14 Sep Depression and pain increase fatigue in breast cancer survivors

Posted at 23:43h in Breast Cancer

In Spain, 5-year survival following breast cancer diagnosis is more than 83%. Around 66% suffer fatigue following treatment. A Spanish research establishes the factors associated with tiredness in cancer survivors to improve their quality of life and rehabilitation. "Cancer-related fatigue is the symptom that most limits quality of life and is...

13 Sep Study: Gene therapy causes breast cancer stem cells to self-destruct

Posted at 00:12h in Breast Cancer, MD Anderson

Targeted agent avoids healthy cells, blocks proteins that prevent cell death in tumors HOUSTON -- Gene therapy delivered directly to a particularly stubborn type of breast cancer cell causes the cells to self-destruct, lowers chance of recurrence and helps increase the effectiveness of some types of chemotherapy, researchers at The University...

08 Sep Study: Chemotherapy is as effective before breast cancer surgery as after

Posted at 23:49h in Breast Cancer

Approach may help some women avoid mastectomy San Francisco, CA - Whether chemotherapy is given before or after breast-conserving therapy (BCT) does not have an impact on long-term local-regional outcomes, suggesting treatment success is due more to biologic factors than chemotherapy timing, according to a study by researchers at The University...

02 Sep Key function of mutation in BRCA1 gene discovered

Posted at 00:21h in Breast Cancer, Cancer Research, Ovarian Cancer

Richmond, Va. (September 1, 2011) –It is widely known that mutations in the breast cancer susceptibility 1 (BRCA1) gene significantly increase the chance of developing breast and ovarian cancers, but the mechanisms at play are not fully understood. Now, researchers at Virginia Commonwealth University Massey Cancer Center have shown that...

19 Aug PET scans confirm effectiveness of estrogen-blocking drugs in breast cancer patients

Posted at 23:47h in Breast Cancer, Cancer Research, Radiology

SEATTLE – For the first time, researchers at Seattle Cancer Care Alliance have demonstrated the feasibility of using serial positron emission tomography (PET) scans, using a special estrogen-containing isotope, to confirm the relative effectiveness of estrogen-blocking and estrogen-depleting therapy in patients with metastatic breast cancer. The results of the research...

16 Aug Breast Feeding & Breast Cancer in African-American women

Posted at 22:47h in Breast Cancer, Cancer Research

Investigators from the Boston University's Slone Epidemiology Center have reported findings that may shed light on why African American women have a disproportionately higher risk of developing more aggressive and difficult-to-treat breast cancers, specifically estrogen and progesterone receptor negative (ER-/PR-) cancers. The study, which appears online in Cancer Epidemiology, Biomarkers &...

11 Aug Report: NSAIDS reduce the severity of postpartum breast cancers in animal models

Posted at 21:39h in Breast Cancer, Nature

Published online on Aug. 7, 2011, the journal Nature Medicine reports that non-steroidal anti-inflammatory drugs including ibuprofen reduce the severity of postpartum breast cancers in animal models. “We caution patients and providers that because a mother’s body is undergoing radical changes during this time, we can’t yet speak to the...

03 Aug New Breast Cancer Strategies Presented at Conference

Posted at 20:24h in Breast Cancer, Cancer Research, Nature

ORLANDO, Fla. — August 3, 2011 — In their lifetime, women have more than a 12 percent risk of being diagnosed with breast cancer. 1 This week, research on novel approaches to breast cancer treatment is being presented at the Era of Hope (EOH) conference, a scientific meeting hosted by...

03 Aug Potential Links between Maternal Diet in Pregnancy and Breast Cancer in Daughters

Posted at 20:18h in Breast Cancer

ORLANDO, Fla. — August 3, 2011 — During pregnancy, women are counseled to refrain from consuming certain types of foods, beverages and medications in order to avoid jeopardizing the health and development of the fetus. In fact, the American Pregnancy Association has a list of a dozen items they recommend...

03 Aug Exploring Breast Cancer Mechanisms of Spread and Treatment Options

Posted at 20:15h in Breast Cancer

ORLANDO, Fla. — August 3, 2011 — Research into new methods to prevent and slow metastatic breast cancer will be presented this week at the Era of Hope conference, a scientific meeting hosted by the Department of Defense Breast Cancer Research Program (BCRP). Approximately 6 percent of women with breast...

01 Aug Combining dasatinib with Tamoxifen, may overcome Tamoxifen resistance in breast cancer

Posted at 20:45h in Breast Cancer

August 1 20100 PHILADELPHIA—Taking a leukemia chemotherapy drug may help breast cancer patients who don't respond to tamoxifen overcome resistance to the widely-used drug, new research from the Kimmel Cancer Center at Jefferson suggests. Interestingly, researchers found that taxoxifen combined with dasatinib, a protein-tyrosine kinase inhibitor, reverses the chemo-resistance caused by cancer-associated...

29 Jul Study examines how blood protein levels change as breast cancer develops before it is clinically detectable

Posted at 01:38h in Breast Cancer, Nature

SEATTLE – Using a "systems biology" approach – which focuses on understanding the complex relationships between biological systems – to look under the hood of an aggressive form of breast cancer, researchers for the first time have identified a set of proteins in the blood that change in abundance long...

28 Jul Breast density tied to specific types of breast cancer

Posted at 15:16h in Breast Cancer, Cancer Research

Women with breasts that appear dense on mammograms are at a higher risk of breast cancer and their tumors are more likely to have certain aggressive characteristics than women with less dense breasts, according to a study published online July 27 in the Journal of the National Cancer Institute. Mammographic breast...

27 Jul Scientists Develop New Therapy for HER2-Positive Breast Cancer

Posted at 10:38h in Breast Cancer, Cancer Research

Newswise — PHILADELPHIA — Patients with HER2-positive breast cancer may have an alternative therapy when they develop resistance to trastuzumab, also known as Herceptin, according to a laboratory finding published in Clinical Cancer Research, a journal of the American Association for Cancer Research. Jacek Capala, Ph.D., D.Sc., an investigator at the...