Author Interviews, Dental Research, Microbiome, University of Pennsylvania / 19.05.2021

MedicalResearch.com Interview with: Geelsu Hwang, Ph.D. Assistant Professor Department of Preventive and Restorative Sciences Center for Innovation and Precision Dentistry (CiPD) School of Dental Medicine University of Pennsylvania MedicalResearch.com: What is the background for this study? What is the significance of this oral biofilm? Response: Dental caries is one of the most common and costly biofilm-dependent diseases that afflict children and adults worldwide. Particularly, Early Childhood Caries (ECC) is a hyper-virulent type of chronic tooth decay that most frequently afflicts underprivileged preschool children. The onset and progression of carious lesions in ECC are rapid and aggressive, causing rampant destruction of the smooth surfaces of teeth. ECC is painful and often requires surgical procedure under general anesthesia, while current treatment modalities are inefficient and recurrence of ECC is common. Notably, interactions between a fungus, Candida albicans, and a bacterium, Streptococcus mutans, have been known to play important roles in the pathogenesis of dental caries. Thus, we attempted to strategically develop a targeted measure to effectively prevent cross-kingdom interactions and subsequent biofilm development. (more…)