Author Interviews, Geriatrics, JAMA, Pharmacology / 05.08.2025
McGill University Develops Software to Help Providers Deprescribe Unnecessary Medications in Older Adults
MedicalResearch.com Interview with:
[caption id="attachment_70179" align="alignleft" width="220"]
Dr. McDonald[/caption]
Emily G. McDonald MD MSc (Epi) FRCPC
Scientist | Research Institute of the McGill University Health Centre
Associate Professor of Medicine | General Internal Medicine | McGill University Health Centre
Associate Chair of Quality and Safety | Department of Medicine | McGill University
Director | Canadian Medication Appropriateness and Deprescribing Network
Centre for Outcomes Research and Evaluation (CORE)
Montreal, QC
https://www.medsafer.org/
https://www.deprescribingnetwork.ca/
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Polypharmacy (taking multiple medications) is common among older adults and can lead to serious side effects like memory problems, falls, fractures, and hospitalization. Deprescribing (the process of stopping some medications that may no longer be beneficial or where the harms outweigh the benefits) is a great solution. This study found that an electronic tool to support prescribers increased deprescribing more than 3 times compared to usual care without the software support.
Dr. McDonald[/caption]
Emily G. McDonald MD MSc (Epi) FRCPC
Scientist | Research Institute of the McGill University Health Centre
Associate Professor of Medicine | General Internal Medicine | McGill University Health Centre
Associate Chair of Quality and Safety | Department of Medicine | McGill University
Director | Canadian Medication Appropriateness and Deprescribing Network
Centre for Outcomes Research and Evaluation (CORE)
Montreal, QC
https://www.medsafer.org/
https://www.deprescribingnetwork.ca/
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Polypharmacy (taking multiple medications) is common among older adults and can lead to serious side effects like memory problems, falls, fractures, and hospitalization. Deprescribing (the process of stopping some medications that may no longer be beneficial or where the harms outweigh the benefits) is a great solution. This study found that an electronic tool to support prescribers increased deprescribing more than 3 times compared to usual care without the software support.
Most news stories tend to focus on how drugs and the opioid epidemic are impacting people in their teens and early adulthood. However, I can tell you from personal experience, that there are a lot of older adults who are also abusing drugs alcohol at record rates. This is borne out at our family’s drug treatment program which I founded and run in San Diego, California.
You may be surprised to hear that the rates of opioid overdose in the U.S. have increased the most among people ages 65 and up (from 2021 to 2022) and that older adults have seen the greatest increase in cannabis use in Canada. One thing you also may not realize is that older adults have the highest recovery rates of all age groups.
Photo by
Dr. Mohyuddin[/caption]
Hira Mohyuddin, PGY-2
Psychiatry Residency Training Program
The George Washington University
MedicalResearch.com: What is the background for this study?
Response: Frailty has become increasingly significant as the global population grows older, as this syndrome is linked with a higher mortality and morbidity in aging. Causes contributing to frailty are poorly understood, but it seems that the role of inflammation is very likely.
While other chronic infections were shown to precipitate and perpetuate inflammation that contributes to the development of frailty, no prior study has previously focused on possible links between Toxoplasma gondii and geriatric frailty. Benefiting from a collaboration with Spanish and Portuguese researchers, we have now tested, for the first time to our knowledge, this possible association.
Dr. Jing Li[/caption]
Jing Li, PhD
Assistant Professor of Health Economics
The Comparative Health Outcomes, Policy and Economics (CHOICE) Institute
University of Washington School of Pharmacy
MedicalResearch.com: What is the background for this study?
Response: Dementia and other cognitive impairment are highly prevalent among older adults in the U.S. and globally, and have been linked to deficiencies in decision-making, especially financial decision-making. However, little is known about the extent to which older adults with cognitive impairment manage their own finances and the characteristics of the assets they manage.