26 Jul Metabolic Risk Factors Leading Up to Onset of Dementia

MedicalResearch.com Interview with:

Maude Wagner

Maude Wagner, PhD Student
Biostatistics Team
Lifelong Exposures, Health and Aging Team
Bordeaux Population Health Research Center
Inserm
Univ. Bordeaux

MedicalResearch.com: What is the background for this study? What are the main findings? 

Response: Many studies haves shown associations between cardiometabolic health and dementia in midlife, but associations later in life remain inconclusive.

This study aimed to model concurrently and to compare the trajectories of major cardiometabolic risk factors in the 14 years before diagnosis among cases of dementia and controls.

This study showed that demented persons presented a BMI decline and lower blood pressure (specifically systolic blood pressure) several years before dementia diagnosis that might be a consequence of underlying disease. In contrast, cases presented consistently higher blood glucose levels up to 14 years before dementia suggesting that high glycemia is a strong risk factor for dementia.

MedicalResearch.com: What should readers take away from your report?

Response: These findings emphasize that blood glucose control, low blood pressure and weight loss could be key components of cardiovascular health management for primary and secondary prevention of dementia in older persons.

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: These trajectories should be extended to midlife or even before (lifecourse epidemiology). Moreover, the combined effect of these factors should be evaluated. 

No disclosures

Citation: 

Wagner M, Helmer C, Tzourio C, Berr C, Proust-Lima C, Samieri C. Evaluation of the Concurrent Trajectories of Cardiometabolic Risk Factors in the 14 Years Before Dementia. JAMA Psychiatry. Published online July 24, 2018. doi:10.1001/jamapsychiatry.2018.2004

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Last Updated on July 26, 2018 by Marie Benz MD FAAD