27 Apr PFAS in Everyday Products May Have Liver Risks

MedicalResearch.com Interview with:

Sarah Rock

Sarah Rock, MPH
PhD student, Department of Population and Public Health Sciences
Keck School of Medicine
University of Southern California

MedicalResearch.com:  What is the background for this study?  What are the main findings? 

Response: Per- and polyfluoroalkyl substances (PFAS) are persistent, man-made chemicals widely used in industry and consumer products. Exposure to these chemicals has been linked to multiple disease outcomes including cancer, glucose dysregulation, and as reported in the current study, liver injury. We compiled results from more than 100PFAS studies in humans and rodents and found consistent evidence that PFAS are related to liver injury.

MedicalResearch.com: What should readers take away from your report? 

Response: The findings of this paper demonstrate convincing evidence that PFAS exposure is related to liver damage. Readers should be made aware that chemicals used in everyday products may have health risks. We need to continue to evaluate the safety of the common industry and consumer products, even after they have made it to the shelf. 

MedicalResearch.com: What recommendations do you have for future research as a result of this work? 

Response: In this study, we evaluated the impact of single PFAS exposure and focused largely on the legacy PFAS, like PFOA and PFOS, as there was limited data on exposure mixtures and newly developed PFAS, like GenX. Next steps in PFAS research should focus on evaluating the health risks of exposure to multiple PFAS mixtures as well as the health risks of the next-generation PFAS, which currently have more limited data.

We have no disclosures to add.  

Citation:

Elizabeth Costello,Sarah Rock,Nikos Stratakis,Sandrah P. Eckel,Douglas I. Walker,Damaskini Valvi,Dora Cserbik,Todd Jenkins,Stavra A. Xanthakos,Rohit Kohli,Stephanie Sisley,Vasilis Vasiliou,Michele A. La Merrill,Hugo Rosen,David V. Conti,Rob McConnell,and Leda Chatzi 2022

Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis
Environmental Health Perspectives 130:4 CID: 046001 https://doi.org/10.1289/EHP10092

[wysija_form id=”3″]

[last-modified]

The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.

Last Updated on April 27, 2022 by Marie Benz MD FAAD