Children With Eczema and Food Allergies At Increased Risk of Developing Asthma Interview with:
“Eczema” by NIAID is licensed under CC BY 2.0Malcolm R. Sears, MB ChB

Firestone Institute for Respiratory Health
St Joseph’s Healthcare and McMaster University
Ontario Canada. What is the background for this study? What are the main findings?

Response: The Canadian Healthy Infant Longitudinal Development (CHILD) Study was initiated in 2008, funded by AllerGen NCA and CIHR, to determine root causes of allergy and asthma.

We recruited 3623 pregnant mothers in 4 centers across Canada and are following 3495 eligible children from pregnancy to age 5 years.

In this paper we describe some of the findings in early childhood, namely that children who develop skin conditions generally called eczema or atopic dermatitis, who are also sensitized to food allergens (milk, egg, peanut) at 1 year are at high risk of developing subsequent asthma, whereas those with these skin conditions but not sensitized are not at such risk. What should clinicians and patients take away from your report?

Response: Early allergic sensitization is a risk factor for subsequent progression of the ‘atopic march’ from dermatitis to asthma. What recommendations do you have for future research as a result of this study?

Response: Longitudinal studies are key to understanding the life-course trajectories of many conditions with origins in early life, including not only asthma and allergy, but cardiovascular disease and metabolic disorders such as obesity and diabetes. It is essential to continue the CHILD study through childhood to further explore these issues.

No disclosures Thank you for your contribution to the community.


Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study
Tran, Maxwell M.Subbarao, P. et al.
Journal of Allergy and Clinical Immunology , Volume 0 , Issue 0 ,

Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions. 

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Last Updated on November 20, 2017 by Marie Benz MD FAAD