Emma Guttman-Yassky

Atopic Dermatitis: Mount Sinai Study Finds Lebrikizumab May Allow Longer Intervals Between Treatments

MedicalResearch.com Interview with:

Emma Guttman-Yassky

Dr. Guttman-Yassky

Emma Guttman-Yassky, M.D., PhD,
Lead investigator of this study
Waldman Professor and
System Chair
Kimberly and Eric J. Waldman Department of Dermatology
Icahn School of Medicine at Mount Sinai, NY


MedicalResearch.com: What is the background for this study?

Response: The idea to test how spacing out treatment or even stopping it affects treatment responses once patients are well controlled. Lebrikizumab it is a potent biologic agent with a relatively long-lasting effect.

MedicalResearch.com: What are the main findings?

  • Patients that were well controlled by lebrikizumab at week 16 on four different things trials were evaluated for maintenance of response on every two or four weeks or off drug (in the mono-therapy trials) and every two and four weeks in the add on TCS studies.
  • The results showed maintenance of response throughout the follow up period of up to one year regardless of dosing regimen (both the every two-weeks and every four weeks showed similar maintenance of response overtime.) Further, a large proportion of patients achieving response at week 16 could also be maintained off drug for the follow up period.

MedicalResearch.com: What should readers take away from your report?

Response: For patients that achieve good disease control and clearance it may be possible to space out administration of the drug to every 4 weeks and perhaps even more in certain situations.

MedicalResearch.com: What recommendations do you have for future research as a results of this study?

Response:  Future research should clarify if any patient subset showed particularly better responses and biomarkers related to better responses that can identify the super responders to this and other treatments.

Disclosures: I was an investigator on the trial.


Maintenance of efficacy and safety with lebrikizumab up to one year of treatment in patients with moderate-to-severe atopic dermatitis with or without topical corticosteroids
Emma Guttman-Yassky

(LB05) – Late-Breaker Session -Presentation at 25th World Congress of Dermatology


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Last Updated on July 18, 2023 by Marie Benz MD FAAD