“Syringe and Vaccine” by NIAID is licensed under CC BY 2.0

HPV Vaccination Associated With Marked Reduction in Invasive Cervical Cancer

MedicalResearch.com Interview with:
Dr. Jiayao Lei PhD
Prof. Pär Sparén PhD
Karolinski Institute

MedicalResearch.com: What is the background for this study?

Response: The efficacy and effectiveness of quadrivalent HPV (qHPV) vaccine protecting against HPV infection, genital warts and high-grade precancerous cervical lesions have been shown. However, there is lack of population-based studies in examining the association between HPV vaccine and invasive cervical cancer on individual level. 

MedicalResearch.com: What are the main findings?

 Response: In this population-based study using nationwide registry data in Sweden, we found that HPV vaccination was associated with a substantially reduced risk of invasive cervical cancer among Swedish girls and women 10 to 30 years old. Girls vaccinated before age 17 reduced their risk of invasive cervical cancer by 88 percent, and women vaccinated between ages 17 and 30 halved their risk of cervical cancer compared to unvaccinated women.

MedicalResearch.com: What should readers take away from your report?

Response: Quadrivalent HPV vaccination is associated with substantially reduced risk of invasive cervical cancer, especially for girls who initiate the vaccination at younger age. 

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: The association between qHPV and risk of invasive cervical cancer for women age older than 30 needs to be investigated. Besides, the association of HPV vaccination and risk of cervical cancer by number of doses of vaccine should also be evaluated in future research.

MedicalResearch.com: Is there anything else you would like to add?

 Response: Our results highlight the significance of HPV vaccination. It is very important to scale-up the coverage of HPV vaccination, especially the coverage in children and adolescents, in order to reduce the burden of cervical cancer. Co-authors Prof. Dillner and Dr. Sundström of this article have received research grants to their institution from Merck and Co., Inc. 


HPV Vaccination and the Risk of Invasive Cervical Cancer
Jiayao Lei, Ph.D., Alexander Ploner, Ph.D., K. Miriam Elfström, Ph.D., Jiangrong Wang, Ph.D., Adam Roth, M.D., Ph.D., Fang Fang, M.D., Ph.D., Karin Sundström, M.D., Ph.D., Joakim Dillner, M.D., Ph.D., and Pär Sparén, Ph.D.

N Engl J Med 2020;383:1340-8. DOI: 10.1056/NEJMoa1917338


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Last Updated on September 30, 2020 by Marie Benz MD FAAD