04 Sep Children Show Can Show Symptoms of Inflammatory Syndrome 3-4 Weeks After COVID-19 Infection

MedicalResearch.com Interview with:

Dr. Moreira

Alvaro Moreira, MD
Assistant Professor, Department of Pediatrics
Co-Director Neonatal Nutrition and Bone Institute
UT Health San Antonio

MedicalResearch.com: What is the background for this study?

Response: Multisystem inflammatory syndrome in children (MIS-C), also known as pediatric inflammatory multisystem syndrome, is a new dangerous childhood disease that is temporally associated with coronavirus disease 2019 (COVID-19).

We conducted a systematic review to communicate the typical presentation and outcomes of children diagnosed with this hyperinflammatory condition. 

MedicalResearch.com: What are the main findings?

Response: 71·0% of children (n = 470) were admitted to the intensive care unit. Fever (100%, n = 662), abdominal pain or diarrhea (73·7%, n = 488), and vomiting (68·3%, n = 452) were the most common clinical presentation. Mechanical ventilation occurred in 22·2% (n = 147) of patients. An abnormal cardiac ultrasound was observed in 54·0% of individuals.

MedicalResearch.com: What should readers take away from your report?

Response: Children will typically show signs/symptoms of MIS-C three to four weeks after COVID-19 infection. Families should seek immediate medical care as children with this condition decompensate quickly and most will need management in an intensive care unit. MIS-C is rare but the potential long-term sequelae from this disease are currently unknown. 

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: Future research should focus on identifying variables that can prognosticate which pediatric COVID-19 patients will develop MIS-C and which, if any, markers correlate with systemic outcomes.

Citation:

Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with SARS-CoV-2: A Systematic Review
Abrams, Joseph Y. et al.
The Journal of Pediatrics, Volume 0, Issue
https://doi.org/10.1016/j.eclinm.2020.100527

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Last Updated on September 4, 2020 by Marie Benz MD FAAD