25 Oct Endometriosis: Biomarker May Allow Personalized Approach to Treatment
MedicalResearch.com Interview with:
Dr. Flores
Valerie A. Flores, MD
Clinical Instructor
Division of Reproductive Endocrinology & Infertility
Department of Obstetrics, Gynecology & Reproductive Sciences
Yale School of Medicine – Yale New Haven Hospital
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Endometriosis is a debilitating gynecologic disease that affects 1 in 10 reproductive-aged women, causing pain and infertility. It is a hormonally dependent disorder— estrogens promote growth of endometriosis, while progesterone inhibits estrogen-dependent proliferation. Although progestin-based therapies (including combined oral contraceptives) are first-line therapy in the management of endometriosis-associated pain, response to progestins is variable and currently unpredictable.
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: A test that predicts response to progestin-based therapy would allow for a personalized approach to treating endometriosis. We found that Progesterone Receptor (PR) status in endometriotic lesions is strongly associated with response to progestin-based therapy.
MedicalResearch.com: What should readers take away from your report?
Response: Receptor status in endometriosis could be used in a manner analogous to the use of ER/PR status in breast cancer for tailoring hormonal-based regimens. Such an approach to endometriosis management would negate trialing progestin-based therapy to determine response, and minimize delays in providing the optimal medical therapy for each individual patient. The utilization of PR status in endometriotic lesions may allow for a novel, targeted approach to treating endometriosis.
Citation:
Valerie A Flores, Arne Vanhie, Tran Dang, Hugh S Taylor; Progesterone Receptor Status Predicts Response to Progestin Therapy in Endometriosis, The Journal of Clinical Endocrinology & Metabolism, https://doi.org/10.1210/jc.2018-01227
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Last Updated on October 25, 2018 by Marie Benz MD FAAD