06 Apr Acute Kidney Injury Risk From PCI Surgery Lower With Radial Approach
MedicalResearch.com Interview with:
Department of Thrombosis and Hemostasis
Leiden University Medical Center
Leiden, The Netherlands
MedicalResearch.com: What are the main findings of the study?
Dr. Kooiman: The main finding of our study is that trans radial PCI (TRI) is associated with a significantly lower risk of AKI compared with trans femoral PCI (TFI), after adjustment for confounding factors.
MedicalResearch.com: Were any of the findings unexpected?
Dr. Kooiman: It is know from previous studies that major bleeding post PCI is associated with AKI. Major bleeding occurred more frequently in our cohort in patients undergoing TRI compared with TFI. We hypothesized that the increased risk of AKI post PCI could be mediated by the increased risk of major bleeding in the TFI group. However, our study results indicated that the increased risk of AKI post TRI was not influenced by the higher bleeding rates in this patient group.
MedicalResearch.com: What should clinicians and patients take away from your report?
Dr. Kooiman: Previous randomized trials have shown a benefit of TRI over TFI in terms of a lower risk of vascular (bleeding) complications. Our observational study adds to the already known benefits of TRI over TFI in terms of a lower AKI risk.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Dr. Kooiman: Over the last decade, several randomized controlled trials comparing TRI with TFI have been performed studying other outcomes such as vascular (bleeding) complications post PCI. It would be very interesting to look at the data from those studies to see whether they can confirm our finding of a lower AKI risk after TRI compared with TFI.
Risk of Acute Kidney Injury After Percutaneous Coronary Interventions Using Radial Versus Femoral Vascular Access: Insights From the Blue Cross Blue Shield of Michigan Cardiovascular Consortium
Judith Kooiman, Milan Seth, Simon Dixon, David Wohns, Thomas LaLonde, Sunil V Rao, and Hitinder S. Gurm
Circ Cardiovasc Interv. 2014;CIRCINTERVENTIONS.113.000778published online before print February 25 2014, doi:10.1161/CIRCINTERVENTIONS.113.000778