27 Mar Cardiac Surgery: No Difference in Outcomes Between Inhaled and IV Anesthesia
MedicalResearch.com Interview with:
Dr. Giovanni Landoni
Intensive Care and Anesthesia Unit
Università Vita-Salute San Raffaele
MedicalResearch.com: What is the background for this study?
Response: Patients undergoing cardiac surgery are still at risk for perioperative complications. Studies to improve clinical outcomes this setting are important. Inhaled anesthetics have pharmacological properties which reduce myocardial infarction size by 50% in laboratory and animal studies and which might decrease postoperative mortality according to aggregated published randomized data.
MedicalResearch.com: What are the main findings?
Response: We studied 5,400 patients undergoing cardiac surgery under inhalation anesthesia or intravenous anesthesia and found that both anesthesia techniques are safe, with no differences in perioperative outcomes and in one year mortality.
MedicalResearch.com: What should readers take away from your report?
- Large academic, collaborative, no profit trials are feasible
- Anesthesia techniques are safe and can be routinely applied to patients around the world
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: It is important that promising findings of small or single center studies are confirmed by large, pragmatic, investigator driven multicenter randomized trials before entering into guidelines.
MedicalResearch.com: Is there anything else you would like to add?
Response: Physicians around the world are now widely connected. It would be important to have less bureaucracy for academic no-profit pragmatic trials. This would allow to perform several of these trials within short time (and not few trials which take several years to be completed). This is in the interest of patients and national health systems, but nobody seem to be aware or to care about it.
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