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Personalized Micronutrients May Benefit Cardiovascular Health

MedicalResearch.com Interview with:

Simin Liu MD MPH ScDProfessor of Epidemiology at the School of Public Health, Professor of Medicine (Endocrinology) and Professor of Surgery at the Alpert School of Medicine Brown University

Dr. Simin Liu

Simin Liu MD MPH ScD
Professor of Epidemiology at the School of Public Health,
Professor of Medicine (Endocrinology) and
Professor of Surgery at the Alpert School of Medicine
Brown University

MedicalResearch.com: What is the background for this study?

Response: Our research team has been researching the roles of environmental and genetic determinants of chronic diseases for nearly three decades, with special emphasis on evaluating micronutrients, minerals, and trace elements in relation to cardiometabolic outcomes, and findings of which have contributed to the design of several large, randomized trials of dietary supplements in the US (Liu JAMA 1999; 2011; Diabetes Care 2005a,b; Diabetes 2006).  Several large intervention trials have consistently shown beneficial effects on clinical cardiometabolic outcomes of a diet pattern rich in micronutrients, although research on micronutrient supplementation has mainly focused on the health effects of a single or a few vitamins and minerals.

We decided to take a comprehensive and systematic approach to evaluate all the publicly available/accessible studies reporting all micronutrients including phytochemicals and antioxidant supplements and their effects on cardiovascular risk factors as well as multiple CVDs.

MedicalResearch.com: What should readers take away from your report?

Response:  A personalized, precision-based dietary intervention involving certain combinations of beneficial micronutrients may promote cardiometabolic health outcomes.

MedicalResearch.com: What recommendations do you have for future research as a results of this study?

Response:  For the first time, we developed a comprehensive evidence-based map for all micronutrient supplements’ potential effects on cardiometabolic outcomes. This would allow for the design of precision-based intervention trials to determine the clinical efficacy of multiple combinations of micronutrients on cardiometabolic health outcomes.

Our study highlights the importance of micronutrient diversity, which could be used to guide the design of future intervention trials to test the optimal combination of micronutrients for cardiometabolic health.

No disclosures


An P, Wan S, Luo Y, et al. Micronutrient Supplementation to Reduce Cardiovascular Risk. J Am Coll Cardiol. 2022 Dec, 80 (24) 2269–2285.https://doi.org/10.1016/j.jacc.2022.09.048


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Last Updated on December 6, 2022 by Marie Benz MD FAAD