14 Mar Frozen Fecal Transplant in Pill Form Found To Reverse C. Diff Infection
MedicalResearch.com Interview with:
Dr. H. L. DuPont MD
Director, Center for Infectious Diseases, UTHealth School of Public Health
Mary W. Kelsey Chair in the Medical Sciences, McGovern Medical School at UTHealth
Professor, Department of Epidemiology, Human Genetics and Environmental Sciences
UTHealth School of Public Health
Houston, TX 77030
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Many diseases and disorders are associated with “dysbiosis,” where the intestinal microbiota diversity is reduced. This contributes to disease and to the acquisition of antibiotic resistance. Fecal microbiota transplantation (FMT) is successful in conditions with pure dysbiosis (e.g. C diff infection) and a single dose of FMT is curative in most cases.
MedicalResearch.com: What should readers take away from your report?
Response: We found frozen fecal microbiota transplantation and freeze-dried (like instant coffee) powder were effective in reversing the disorder. This will make treatment available to many people with C-diff and open the door to treat the various disorders, from C diff to obesity, with capsules of lyophilized powder.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Response: The reversal of the intestinal microbiome is one of the most exciting fields of medicine and may open new areas of treatment.
MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.
Z. D. Jiang, N. J. Ajami, J. F. Petrosino, G. Jun, C. L. Hanis, M. Shah, L. Hochman, V. Ankoma-Sey, A. W. DuPont, M. C. Wong, A. Alexander, S. Ke, H. L. DuPont. Randomised clinical trial: faecal microbiota transplantation for recurrent Clostridum difficile infection – fresh, or frozen, or lyophilised microbiota from a small pool of healthy donors delivered by colonoscopy. Alimentary Pharmacology & Therapeutics, 2017; 45 (7): 899 DOI: 10.1111/apt.13969
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