4-Dose Hepatitis B Vaccine Schedule For HIV Patients Induces Longer Protection

MedicalResearch.com Interview with:

Odile Launay MD, PhD Paris Descartes University Assistance Publique Hôpitaux de Paris, Cochin Hospital

Dr. Odile Launay

Odile Launay MD, PhD
Paris Descartes University
Assistance Publique Hôpitaux de Paris, Cochin Hospital 

MedicalResearch.com: What is the background for this study? What are the main findings?

Dr. Launay: In patients with HIV infection, responses to standard HBV vaccination regimens remain suboptimal compared with responses in HIV seonegative individuals. We previously reported that alternative regimens (a 4 injection IMdouble dose regimen and a 4 injection intradermal low dose regimen) improve antibody response compared with the standard HBV vaccination regimen (ANRS HB03 VIHVAC-B study). Further precision on the duration of response achieved with alternative HBV vaccination regimes was needed.

We report in this paper the results from the follow-up of the study.

The results of this study show that the 4 dose IM regimen induces higher seroconversion rate but also higher long term seroprotection in HIV infected patients

MedicalResearch.com: What should clinicians and patients take away from your report?

Dr. Launay: The 4-dose intramuscular regimen is well tolerated and induces higher and more prolongated seroprotection that the standard regimen. It should become the standard for HBV vaccination in HIV infected patients. 

MedicalResearch.com: What recommendations do you have for future research as a result of this study?

Dr. Launay: Further studies are needed to evaluate the clinical protection conferred by higher immune response to HBV vaccination

MedicalResearch.com: Thank you for your contribution to the MedicalResearch.com community.


Launay O, Rosenberg AR, Rey D, et al. Long-term Immune Response to Hepatitis B Virus Vaccination Regimens in Adults With Human Immunodeficiency Virus 1: Secondary Analysis of a Randomized Clinical Trial. JAMA Intern Med. Published online April 11, 2016. doi:10.1001/jamainternmed.2016.0741. 

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Last Updated on April 13, 2016 by Marie Benz MD FAAD