13 Apr 4-Dose Hepatitis B Vaccine Schedule For HIV Patients Induces Longer Protection
MedicalResearch.com Interview with:
Odile Launay MD, PhD
Paris Descartes University
Assistance Publique Hôpitaux de Paris, Cochin Hospital
MedicalResearch.com: What is the background for this study? What are the main findings?
Dr. Launay: In patients with HIV infection, responses to standard HBV vaccination regimens remain suboptimal compared with responses in HIV seonegative individuals. We previously reported that alternative regimens (a 4 injection IMdouble dose regimen and a 4 injection intradermal low dose regimen) improve antibody response compared with the standard HBV vaccination regimen (ANRS HB03 VIHVAC-B study). Further precision on the duration of response achieved with alternative HBV vaccination regimes was needed.
We report in this paper the results from the follow-up of the study.
The results of this study show that the 4 dose IM regimen induces higher seroconversion rate but also higher long term seroprotection in HIV infected patients
MedicalResearch.com: What should clinicians and patients take away from your report?
Dr. Launay: The 4-dose intramuscular regimen is well tolerated and induces higher and more prolongated seroprotection that the standard regimen. It should become the standard for HBV vaccination in HIV infected patients.
MedicalResearch.com: What recommendations do you have for future research as a result of this study?
Dr. Launay: Further studies are needed to evaluate the clinical protection conferred by higher immune response to HBV vaccination
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