One example of melanoma from DermNet NZ

Melanoma: Florescent Biomarkers Detectable in Urine Interview with:
Dr. Ivana Špaková

Pavol Jozef Šafárik University
Košice, Slovakia What is the background for this study?

Response:  The background is the plenty of space for studying “waste metabolites” which tell us more about the metabolism of the whole body as well as about the metabolism of the smallest compartment – cell. So we decided to study what is the difference in urine spectra (absorbance, excitation, and emission spectra) in patients with malignant melanoma and healthy subjects without positive cancer history. What are the main findings?

Response: The main findings are “discovery” (it is not true discovery because the target molecules or metabolites are known for decades) of molecules{metabolites which together describe the stage of malignant melanoma. These findings could be used for future tracking the patient’s response for treatment or for tracking the previously treated patients for malignant melanoma and are healthy at the moment of sampling. 

One example of melanoma from DermNet What should readers take away from your report?

Response: Readers from the scientific field, or from the medical field could start to think about using the urine samples for more than “only” to find out for conventional metabolites of conventional diseases (understood as kidney disorders, Diabetes melitus, etc.). In the urine hides more than we think. Readers from the public who have this bad disease or who like to read about “new views in old biochemical testing” could start to ask for using this analytic method. Then this method has a chance to be widely used in routine. What recommendations do you have for future research as a result of this work?

 Response: We think that there is still a lot to study. We need to identify the differences in “urine spectra” of different cancers or chronic diseases. We think that for future research in the “urine malignant melanoma field” we have to be focused in identification of one or two more metabolites which will specifically correspond with the disease. 

Please see article for disclosures


Ivana Špaková, Katarína Dubayová, Vladimíra Nagyová, Mária Mareková. Fluorescence biomarkers of malignant melanoma detectable in urine. Open Chemistry, 2020; 18 (1): 898 DOI: 10.1515/chem-2020-0143


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Last Updated on August 14, 2020 by Marie Benz MD FAAD