01 Sep Gut Fungus Linked to Alzheimer’s Disease
MedicalResearch.com Interview with:
Hariom Yadav, PhD
Assistant Professor, Molecular Medicine
Wake Forest School of Medicine
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: As gut microbiota is linked with all kind of known human diseases, however, commonly studied microorganisms are bacteria. Our study is first-of-its kind to discover the role of fungi living in our gut to influence our brain health like Alzheimer’s disease pathology in humans. It also describes that a Mediterranean ketogenic diet can beneficially change fungi and bacteria populations to improve brain health.
MedicalResearch.com: What should readers take away from your report?
Response: For scientific audiences, this study open new avenues to further study how the fungal population (mycobiome) living in our gut impact brain health, and how we can manipulate them to mitigate brain diseases like Alzheimer’s disease. For general public audiences, it is important to keep watch on our diet- what kind of fungi it can bring to our gut and that can influence our brain.
MedicalResearch.com: What recommendations do you have for future research as a result of this work?
Response: Future studies need to precisely define what are good and bad fungi living in our gut, what are there sources, and how they influence our brain health, to pave the ways to improve gut-brain health.
All disclosures are reported in manuscript.
Ravinder Nagpal, Bryan J. Neth, Shaohua Wang, Sidharth P. Mishra, Suzanne Craft, Hariom Yadav. Gut mycobiome and its interaction with diet, gut bacteria and alzheimer’s disease markers in subjects with mild cognitive impairment: A pilot study. EBioMedicine, 2020; 59: 102950 DOI: 10.1016/j.ebiom.2020.102950
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