29 Mar New Test Aims for Early Detection of Sepsis Utilizing Coagulation Factors
MedicalResearch.com Interview with:
Michael J. Mahan Ph.D.
Dept of Molecular, Cellular, and Developmental Biology
University of California
Santa Barbara, CA
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Sepsis is the number one cause of death in US hospitals- but few molecular diagnostics and therapies exist for this condition. In the clinic, sepsis is diagnosed by a symptom-based approach that may include kidney or liver failure, blood clotting or bleeding — which is often well after permanent organ damage.
Thus, molecular diagnostics that detect infection at early stages of disease to minimize host injury are sorely needed.
MedicalResearch.com: What are the main findings?
Response: We have developed a new test that predicts sepsis soon after infection in mice — well before blood clotting and organ failure —enabling early sepsis treatment resulting in markedly increased survival.
MedicalResearch.com: What should readers take away from your report?
Response: The findings provide a platform to develop rapid and easy-to-perform clinical tests for early sepsis detection and clinical intervention in human patients.
Coagulation factor protein abundance in the pre-septic state predicts coagulopathic activities that arise during late-stage murine sepsis
Heithoff, Douglas M. et al.
eBioMedicine, Volume 78, 103965
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