Stroke Raises Risk of Kidney Failure Requiring Dialysis

Charuhas V. Thakar, MD, FASN Professor of Medicine Director, Division of Nephrology and Hypertension University of Cincinnati Cincinnati, OH 45267

Dr. Charuhas Thakar

MedicalResearch.com Interview with:
Charuhas V. Thakar, MD, FASN
Professor of Medicine
Director, Division of Nephrology and Hypertension
University of Cincinnati
Cincinnati, OH  45267

 Medical Research: What is the background for this study? What are the main findings?

Dr. Thakar: This study confirms the association between Acute Kidney Injury (AKI) and mortality in Stroke .

  • The new contributions are that we were among the first to do a trend analysis in a national sample – and it shows that the incident rate of Acute Kidney Injury after stroke is increasing, and risk of adverse discharge and mortality remains high.
  • The rate of AKI is higher in Intra-Cerebral Hemorrhage (ICH) compared to Acute Ischemic Stroke (AIS).
  • Atrial Fibrillation, Hypertension and CKD were commonly associated with AKI in stroke subjects .

Medical Research: What should clinicians and patients take away from your report?

Dr. Thakar: 

  • Acute Kidney Injury was associated with high risk of adverse discharge – defined as nursing home or long term acute care.
  • We need to learn the mechanisms of  interplay between two vital organs when one undergoes ischemic injury – the so called “cerebro-renal” connection.

Medical Research: What recommendations do you have for future research as a result of this study?

Dr. Thakar:   We as a healthcare system need to be prepared for increasing burden of patients who will continue to require complex acute care – given that overall incidence of Acute Kidney Injury is increasing and the absolute mortality rate in stroke is decreasing.

Citation:

Girish N. Nadkarni, Achint A. Patel, Ioannis Konstantinidis, Abhimanyu Mahajan, Shiv Kumar Agarwal, Sunil Kamat, Narender Annapureddy, Alexandre Benjo, and Charuhas V. Thakar.
Dialysis Requiring Acute Kidney Injury in Acute Cerebrovascular Accident Hospitalizations.
Stroke, October 2015 DOI: 10.1161/STROKEAHA.115.010985

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Charuhas V. Thakar, MD, FASN (2015). Stroke Raises Risk of Kidney Failure Requiring Dialysis 

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