Surgical Castration Linked To Fewer Side Effects Than Androgen Deprivation in Prostate Cancer

04 Jan Surgical Castration Linked To Fewer Side Effects Than Androgen Deprivation in Prostate Cancer

Posted at 14:04h in Author Interviews, Brigham & Women's - Harvard, JAMA, Prostate Cancer, Surgical Research, Testosterone by Marie Benz MD FAAD

Dr. Trinh

MedicalResearch.com Interview with:
Quoc-Dien Trinh MD
Assistant Professor, Harvard Medical School
Brigham and Williams Hospital

Medical Research: What is the background for this study? What are the main findings?

Dr. Trinh: Among elderly Medicare beneficiaries with metastatic prostate cancer, surgical castration is associated with lower risks of any fractures, peripheral arterial disease, and cardiac-related complications compared to medical castration using GnRH agonists.

Medical Research: What recommendations do you have for future research as a result of this study?

Dr. Trinh: I find it disconcerting that a perfectly reasonable, cost-effective surgical treatment with potentially less adverse effects and compliance issues than its pharmacologic equivalent has disappeared from medical practice for non-scientific reasons.

Citation:

Maxine Sun, Toni K. Choueiri, Ole-Petter R. Hamnvik, Mark A. Preston, Guillermo De Velasco, Wei Jiang, Stacy Loeb, Paul L. Nguyen, Quoc-Dien Trinh. Comparison of Gonadotropin-Releasing Hormone Agonists and Orchiectomy.

JAMA Oncology, 2015; 1 DOI:10.1001/jamaoncol.2015.4917

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Quoc-Dien Trinh MD (2016). Surgical Castration Linked To Fewer Side Effects Than Androgen Deprivation in Prostate Cancer

Last Updated on January 4, 2016 by Marie Benz MD FAAD