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Vitamin D Supplements During Pregnancy Linked to Decreased Tooth Enamel Defects in Children

MedicalResearch.com Interview with:
Hans Bisgaard, DMSc, MD
Head of COPSAC, Professor
Professor of Pediatrics, University of Copenhagen
Founder and Head of the Copenhagen Prospective Studies on Asthma in Childhood;
Gentofte Hospital, University of Copenhagen and Naestved Hospital

MedicalResearch.com: What is the background for this study?

Response: Enamel defects is a global health challenges affecting typically 1/3 of school children and more in some regions. It leads to break down of the teeth and caries later on.

MedicalResearch.com: What are the main findings?

Response: Supplementation with high-dose vitamin D compared to standard dose in the third pregnancy trimester in a mother child cohort of 588 pairs lead to a significant reduction of enamel defects.

Enamel defects was found in 28% of children by age 6 after standard dose of vitamin D supplementation (400 i.u.), compared to 15% after 7-fold higher dose vitamin D. 

MedicalResearch.com: What should readers take away from your report?

Response: This suggest the current dose recommendations of vitamin supplementation during pregnancy may need to be revised. Particularly since we also found preventive effective on asthma-like symptoms from high-dose vitamin D supplementation

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: The results needs to be replicated in other settings.
 No disclosures


Nørrisgaard PE, Haubek D, Kühnisch J, et al. Association of High-Dose Vitamin D Supplementation During Pregnancy With the Risk of Enamel Defects in OffspringA 6-Year Follow-up of a Randomized Clinical TrialJAMA Pediatr. Published online August 05, 2019. doi:10.1001/jamapediatrics.2019.2545

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Last Updated on August 6, 2019 by Marie Benz MD FAAD