Blood pressure monitor reading 120/80 copyright American Heart Association

Elevated Blood Pressure At Night Linked to Increased Risk of Heart Disease Interview with:
Kazuomi Kario, MD, PhD, FACP, FACC, FAHA, FESC, FJCS

Professor, Chairman
Division of Cardiovascular Medicine, Department of Medicine,
Jichi Medical University School of Medicine (JMU)
JMU Center of Excellence, Cardiovascular Research and Development (JCARD)
Hypertension Cardiovascular Outcome Prevention and Evidence in Asia (HOPE Asia) Network
Shimotsuke, Tochigi, 329-0498, JAPAN What is the background for this study?

Response: To date, it remains unclear whether disrupted blood pressure (BP) circadian rhythm is associated with adverse outcomes independent of nighttime BP.

The JAMP study includes 6359 outpatient population who had ambulatory BP monitoring to evaluate the association between both nocturnal hypertension and nighttime BP dipping patterns and the occurrence of cardiovascular events in patients with hypertension. What are the main findings?

Response: This largest prospective ABPM study to date showed that nighttime blood pressure and a riser pattern of nighttime blood pressure were significantly and independently associated with the risk of Atherosclerotic Cardiovascular Disease and Heart Failure events. What should readers take away from your report?

Response: The earlier and the lower blood pressure control throughout a 24-hour period including nighttime is important for reducing cardiovascular events especially for the high-risk patients. Earlier detection and management of nocturnal hypertension will contribute to reduce the risk of Atherosclerotic Cardiovascular Disease and Heart Failure events. What recommendations do you have for future research as a result of this work?

Response: An intervention study to reduce nighttime blood pressure level <120 mmHg. Is there anything else you would like to add?

Response: This study was financially supported in part by a grant from the Foundation for the

Development of the Community (Tochigi).


Kazuomi Kario has received research funding from Omron Healthcare Co., Fukuda Denshi, and A&D Co. None of the other authors have any conflicts of interest to disclose.


Nighttime Blood Pressure Phenotype and Cardiovascular Prognosis: Practitioner-Based Nationwide JAMP Study

Kazuomi Kario , Satoshi Hoshide , Hiroyuki Mizuno , Tomoyuki Kabutoya , Masafumi Nishizawa , Tetsuro Yoshida , Hideyasu Abe , Tomohiro Katsuya , Yumiko Fujita , Osamu Okazaki , Yuichiro Yano , Naoko Tomitani , and Hiroshi Kanegae On behalf of the JAMP Study Group

Originally published2 Nov 2020 ;0



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Last Updated on November 5, 2020 by Marie Benz MD FAAD