“Cancer awareness” by Susan Roberts is licensed under CC BY 2.0

Young Survivors of Cancer at Increased Risk of Endocrine Disease

MedicalResearch.com Interview with:
“Cancer awareness” by Susan Roberts is licensed under CC BY 2.0Mette Vestergaard Jensen, MD

Danish Cancer Society Research Center

MedicalResearch.com: What is the background for this study?

Response: Cancer survival rates have improved and it is necessary to explore the long-term consequences of cancer treatment. Adolescents and young adults with cancer are at risk for several therapy-related late effects; however, these have not been studied extensively. We investigatet the lifetime risks of endocrine late effects of cancer and cancer treatment in adolescent and young adult cancer s

MedicalResearch.com: What are the main findings?

Response: Survivors of cancer in adolescence and young adulthood are at increased risk for endocrine diseases (RR: 1.73). Thyroid disease, testicular dysfunction and diabetes were leading reasons to hospital contacts. Leukemia survivors were at highest risk for any endocrine disease, while Hodgkin lymphoma survivors had the highest disease-specific excess risk for hypothyroidism. 

MedicalResearch.com: What should readers take away from your report? 

Response: The increased risk for endocrine diseases in adolescent and young adult cancer survivors indicates the need for counseling and follow-up, and could guide future preventive measures and surveillance strategies.

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: We hope that this study will inspire investigators in future studies to determine exact associations between treatment regimens and endocrine disease and ultimately incorporate them into individual, customized treatment plans. Each future adolescent and young adult cancer patient should be offered the least deleterious treatment to ensure high quality of life after cancer while maintaining the good cure rates.


Jensen MV, Rugbjerg K, de Fine Licht S, et al. Endocrine Late Effects in Survivors of Cancer in Adolescence and Young AdulthoodA Danish Population-Based Cohort StudyJAMA Network Open. 2018;1(2):e180349. doi:10.1001/jamanetworkopen.2018.0349

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Last Updated on July 2, 2018 by Marie Benz MD FAAD