Alzheimer's - Dementia, Author Interviews, JAMA, Mental Health Research, UCSF / 26.04.2013

MedicalResearch.com eInterview with Dr. David Perry UCSF School of Medicine Clinical Fellow in Neurology 675 Nelson Rising Lane San Francisco CA 94158 MedicalResearch.com: What are the main findings of the study? Dr. Perry: We described two patients with clinical syndromes and brain imaging patterns that are consistent with Alzheimer’s disease. Both were found to have mutations in GRN, which are typically associated with inherited frontotemporal dementia. They both showed evidence of underlying Alzheimer’s pathology, in one case through autopsy confirmation (demonstrating Alzheimer’s disease in addition to TDP-43 pathology), and in the other case from a positive amyloid PET scan. (more…)
Alzheimer's - Dementia, Depression, Mental Health Research / 22.03.2013

Laura B. Zahodne, PhD Postdoctoral fellow in the cognitive neuroscience division in the Department of Neurology and the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain Columbia University Medical Center.MedicalResearch.com Interview with: Laura B. Zahodne, PhD Postdoctoral fellow in the cognitive neuroscience division in the Department of Neurology and the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain Columbia University Medical Center. MedicalResearch.com: What are the main findings of the study? Dr. Zahodne: Having more depressive symptoms early on in Alzheimer’s disease was associated with more rapid declines in the ability to handle tasks of everyday living, and this relationship was independent of cognitive decline. MedicalResearch.com: Were any of the findings unexpected? Dr. Zahodne: Previous studies have shown that depressive symptoms are associated with more difficulties with thinking and daily activities. This study additionally shows that depressive symptoms herald not only more rapid declines in thinking, but also daily functioning, over time. (more…)