“Diabetes Test” by Victor is licensed under CC BY 2.0

Two-Day Fast Per Week vs Daily Calorie Restriction in Diabetes

MedicalResearch.com Interview with:
“Diabetes Test” by Victor is licensed under CC BY 2.0Sharayah Carter
PhD candidate|BNutDiet|BMedPharmSc (Hons)|APD
School of Pharmacy and Medical Sciences
University of South Australia

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: Intermittent energy restriction is a new popular diet method with promising effects on metabolic function but limited research exists on its effects on improving glycemic control in people with type 2 diabetes.

The findings of our research demonstrate that a diet with 2-days of severe energy restriction per week is comparable to a diet with daily moderate energy restriction for glycaemic control. 

MedicalResearch.com: What should readers take away from your report?

  1. A 2-day energy restricted diet is comparable to a daily energy restriction for glycemic improvement (HbA1c) over a 12-month period.
  2. Weight loss is also similar and may be superior with intermittent restriction.
  3. Fasting blood glucose, lipids levels and changes to body composition are also similar using both diet methods over 12 months.
  4. The 2-day diet is safe to use for people using medications not likely to cause hypoglycaemia but requires regular monitoring and medication changes if using glycemic agents likely to cause hypoglycemia. 

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

  1. Further refining of the medication management protocol is required using continuous/flash glucose monitoring to ensure safety in people using glycemic agents likely to cause hypoglycemia.
  2. Further investigation with a larger sample size is required to determine if weight loss is superior using intermittent restriction.
  3. Follow-up 12 months after the intervention period would be useful to determine if intermittent restriction is easier to maintain.

No disclosures.


Carter S, Clifton PM, Keogh JB. Effect of Intermittent Compared With Continuous Energy Restricted Diet on Glycemic Control in Patients With Type 2 DiabetesA Randomized Noninferiority TrialJAMA Network Open.2018;1(3):e180756. doi:10.1001/jamanetworkopen.2018.0756

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Last Updated on July 24, 2018 by Marie Benz MD FAAD