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Photo by Raymond Petrik:[/caption]
The health of your skin is often considered an external issue. However, your skin’s condition can reflect what’s happening inside your body, particularly in relation to your diet. In recent years, research has highlighted the importance of nutrition in maintaining healthy skin. Whether you are dealing with acne, eczema, or aging skin, what you eat plays a crucial role in its appearance and function.
Understanding how food impacts your skin can be the key to better skin health and effective management of skin conditions. Let’s dive into the science of diet and skin health and explore how specific nutrients can affect your complexion.
Photo by Raymond Petrik:[/caption]
The health of your skin is often considered an external issue. However, your skin’s condition can reflect what’s happening inside your body, particularly in relation to your diet. In recent years, research has highlighted the importance of nutrition in maintaining healthy skin. Whether you are dealing with acne, eczema, or aging skin, what you eat plays a crucial role in its appearance and function.
Understanding how food impacts your skin can be the key to better skin health and effective management of skin conditions. Let’s dive into the science of diet and skin health and explore how specific nutrients can affect your complexion.
Dr. Kamath[/caption]
Dr. Suneel Kamath MD
Gastrointestinal Oncologist
Cleveland Clinic
Senior Author on this research
MedicalResearch.com: What is the background for this study?
Response: Colorectal cancer rates in young people under age 50 are skyrocketing and have been for the last 3-4 decades. We really don’t understand why because most cases (probably around 70%) are not genetic or hereditary, just random, unfortunate events. We suspect that it is some exposure(s) like excess consumption of red meat, processed foods, sugar-sweetened beverages, excess antibiotic use altering the microbiome, rising incidence of obesity or some other factors. We really don’t know why yet.
Our study used a technology called metabolomics, the study of breakdown products and production building blocks for our bodies, to look for differences in colorectal cancer in young people versus people that are older that developed colorectal cancer. Because metabolomics measures how each individual interacts with the exposures in our environment like diet, air quality, etc., it is a way to bridge the gap between our nature (determined by genetics) and nurture (determined by our exposures).
Dr. Aronne[/caption]
Dr. Louis Aronne, MD, FACP
Chief Medical Officer, Intellihealth
Medical Director, Comprehensive Weight Control Center
Weill Cornell Medicine
MedicalResearch.com: What is the background for the study “Effect of an Online Weight Management Program Integrated With Population Health Management on Weight Change: A Randomized Clinical Trial”?
Response: More than 70% of U.S. adults have overweight or obesity. Online programs promoting lifestyle change have had some success in helping people achieve and maintain weight loss, but study results have been variable, and these programs have not been widely implemented in primary care. We studied the effectiveness of an online program we have developed (Intellihealth, formerly known as BMIQ) in routine primary care practices, both alone and integrated with population health management (with participants receiving additional support and outreach from nonclinical staff). The study’s objective was to determine whether a combined intervention integrating online weight management with population health management would increase weight loss at 12 months among primary care patients compared with the online program only and usual care.
Dr. Dunn[/caption]
Dr. Amy Dunn, PhD
Kaczorowski lab
The Jackson Laboratory
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Environmental factors, such as a poor diet, are known risk factors for Alzheimer’s disease. But the mechanisms are complex, and it is not known how such environmental perturbations interact with individual genetic variation to confer disease risk. Previous studies have not adequately addressed how the combination of genetic variant and environmental factors combine to alter cognitive response to a poor diet.
To investigate gene-by-environment interactions, we fed either a normal diet or a high-fat diet to a genetically diverse Alzheimer’s disease mouse model population starting at six months of age and monitored metabolic and cognitive function.
We observed accelerated working memory decline in the mice on the high-fat diet after eight weeks, with substantial gene-by diet effects on both cognitive and metabolic traits.
Metabolic dysfunction was more closely related to cognitive function in mice carrying Alzheimer’s mutations than in those without. Interestingly, the high-fat diet affected metabolic function differently in female versus male mice. 
