23 Jan Monoclonal Antibody Offers Hope For Patients With Thyroid Eye Disease
MedicalResearch.com Interview with:
Dr. Douglas
Raymond S Douglas MD PhD
Professor of Surgery, Division of Ophthalmology
Director of the Orbital and Thyroid Eye Disease Program
Cedars Sinai Medical Center
MedicalResearch.com: What is the background for this study?
Response: Thyroid eye disease (TED) is a debilitating disease that affects all aspects of a patients life. It is often associated with Graves’ disease and thyroid abnormalities. TED causes profound bulging of the eyes impairing vision, causing eye pain and facial disfigurement.
MedicalResearch.com: What are the main findings?
Response: The article details the use of teprotumumab, a human monoclonal antibody which binds and inhibits the IGF-1R (insulin like growth factor 1 receptor.) This drug was tested in patients with thyroid eye disease and found to effectively reverse the proptosis, inflammation and diplopia associated with the disease. The drug was rapidly effective achieving response in two doses or 6 weeks of administration. The drug was also well tolerated.
This study demonstrates that medical treatment with teprotumumab is effective at reversing the manifestations of disease, providing new hope for patients
MedicalResearch.com: What should readers take away from your report?
Response: Given the profound results of the study, I believe we are on the verge of a new paradigm in the treatment of this disease.
Disclosures: Dr. Douglas is consultant for Horizon therapeutics 2019 2020
Citation:
Teprotumumab for the Treatment of Active Thyroid Eye Disease
Raymond S. Douglas, M.D., Ph.D., George J. Kahaly, M.D., Ph.D., Amy Patel, M.D., Saba Sile, M.D., Elizabeth H.Z. Thompson, Ph.D., Renee Perdok, M.S., James C. Fleming, M.D., Brian T. Fowler, M.D., Claudio Marcocci, M.D., Michele Marinò, M.D., Alessandro Antonelli, M.D., Roger Dailey, M.D.,
January 23, 2020
N Engl J Med 2020; 382:341-352
DOI: 10.1056/NEJMoa1910434
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Last Updated on January 23, 2020 by Marie Benz MD FAAD