Chronic Hives In Children Resolve Slowly Interview with:

Hives-Urticaria Wikipedia image

Wikipedia image

Elena Netchiporouk, MD, FRCPC, MSc
Dermatology Resident – PGY5 and
Dr. Moshe Ben-Shoshan, MD, FRCPC, MSc
McGill University What is the background for this study?

Response: We have followed a pediatric cohort of 139 patients with chronic urticaria (CU) (hives) between 2013 and 2015 in a single tertiary care center and assessed the comorbidities, the rate of resolution and determined predictors of resolution. What are the main findings?

Response: The rate of disease resolution was low, 10.3% per year. High BAT [basophil activation test (surrogate for autoimmune chronic urticaria ) ] and low serum basophils were associated with earlier disease resolution. What should clinicians and patients take away from your report?

Response: Pediatric chronic urticaria (hives) has a low rate of resolution. Certain biomarkers such as BAT and basophil count may help to prognosticate disease resolution. Hence, surprisingly autoimmune urticaria may have a better prognosis in children. What recommendations do you have for future research as a result of this study?

Response: Similar large-scale studies are needed in both adult and pediatric population to confirm and validate our findings. Studies elucidating the mechanisms accounting for these associations are required in order to better understand the pathogenesis of chronic urticaria  and in order to develop appropriate management strategies. Is there anything else you would like to add?

Response: Our study is based on a tertiary care referral center. Given the waiting time to be seen in a Canadian tertiary care setting, the disease resolution found in our study may underestimate the rate in the primary care setting. Thank you for your contribution to the community.


Netchiporouk E, Sasseville D, Moreau L, Habel Y, Rahme E, Ben-Shoshan M. Evaluating Comorbidities, Natural History, and Predictors of Early Resolution in a Cohort of Children With Chronic Urticaria. JAMA Dermatol.Published online September 27, 2017. doi:10.1001/jamadermatol.2017.3182


Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions. 

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Last Updated on September 28, 2017 by Marie Benz MD FAAD