Cannabis, Pain Research / 02.12.2024

Editor’ note:  Cannabis and THCA/HEMP CBD products should have an active ingredient list on the container and have a Certificate of Analysis (COA). Discuss your use of CBD products with your health care provider.  Dosing of CBD is variable, especially since it is not FDA regulated. CBD may interfere with other medications and should not be used in individuals with certain health conditions, including liver issues. CBD skin care products can be aborbed through the skin and have similar effects. Do not use Cannabis products including edibles and CBD if you are pregnant, nursing or may become pregnant. Do not use cannabis products if driving or operating difficult or dangerous machinery. Children should not be exposed to cannabis or CBD products. Medicinal cannabis is a revolutionary approach to pain management, particularly in patients where conventional medications fail to offer them adequate relief or create intolerable side effects. With ongoing research on cannabis and its medicinal properties, its effectiveness for pain relief has become more convincing. Here are some reasons why medicinal cannabis has risen in popularity in pain management.

Natural Pain Relief Without Risks from Opioids

Many countries have been grappling with an opioid crisis, which has motivated patients to seek cannabis as a much safer alternative. Medicinal cannabis minimizes the risks of addiction associated with opioids due to misuse and gives no risks of an overdose. To obtain medicinal cannabis legally, there are options like medical marijuana cards you can obtain from providers such as Leafy Doc Mississippi. Regarding how cannabis works in terms of pain relief, cannabinoids like THC bind to receptors in the brain and the immune system, modulating the experience of pain. The endocannabinoid system engages with trauma states mainly on account of pain, mood regulation, and inflammation. However, for long-term relief, medicinal cannabis is viewed as a considerably safer alternative compared to opioids. (more…)
Cannabis / 07.10.2024

  In recent years, Florida has seen significant growth in the medical cannabis industry. This expansion has transformed healthcare options for patients across the state. Medical cannabis is now being accepted as a viable treatment for various medical conditions. It is providing new alternatives for those seeking relief from chronic pain, anxiety, and other health issues. With the increasing acceptance of cannabis, Florida dispensaries are making a difference in people's lives. These establishments are vital in enhancing patient care and offering personalized treatment options. A Florida dispensary focuses on promoting wellness through education and support. They contribute significantly to Florida's healthcare landscape, helping improve patient outcomes.  (more…)
Cannabis / 07.10.2024

  The search for natural pain relief and wellness solutions has led many to rediscover the therapeutic power of CBD. When combined with massage therapy, CBD oils may offer a powerful synergy, potentially promoting relaxation, reducing inflammation, and alleviating chronic discomfort. This blend of science-backed benefits and holistic care transforms a simple massage into a deeply rejuvenating experience. As more people seek non-invasive alternatives for their health, CBD-infused massage therapy may help  provide an effective option for mind and body healing. (more…)
Cannabis / 12.09.2024

Editor's note: Please remember the products described below are not FDA tested or approved. The use of edibles can cause unpredictable and potentially serious side effects, including addiction. No cannabinoids in any form should be used while pregnant, nursing or planning to become pregnant. Be sure to avoid driving or any activity which requires mental alertness. It is also important to recognized that these products are not legal in all jurisdictions.  As more people explore the benefits of cannabis, THC edibles have become an increasingly popular way to experience its effects. For beginners, however, edibles can be a little intimidating due to their differences from smoking or vaping cannabis. This guide aims to break down what you need to know about THC edibles, from how they work in the body to tips on choosing safe and reputable products.

How THC Edibles Differ from Smoking or Vaping

When you consume THC through smoking or vaping, it enters your bloodstream quickly via your lungs, leading to effects within minutes. This rapid onset allows users to better control their dose and understand their tolerance more quickly. However, smoking or vaping comes with potential risks to the respiratory system, especially with long-term use. THC edibles, on the other hand, take a different route through the body. When you eat an edible, the THC is absorbed through your digestive system and processed by the liver, which converts it into 11-Hydroxy-THC. This metabolite is known to produce stronger and longer-lasting effects compared to the THC that enters the bloodstream through smoking. However, it also takes longer for these effects to kick in—usually between 30 minutes to two hours. For this reason, beginners should exercise patience and avoid taking additional doses too soon, as it’s easy to overconsume without realizing it. (more…)
Addiction, Author Interviews, Cannabis / 05.08.2024

MedicalResearch.com Interview with: Luke Cavanah, BS Department of Medical Education Geisinger Commonwealth School of Medicine Scranton, PA 18509 MedicalResearch.com: What is the background for this study? Response: Amphetamine, lisdexamfetamine, and methylphenidate, are first-line treatments for attention-deficit hyperactivity disorder (ADHD) and are classified as Schedule II stimulants due to their risk of addiction. (1–3) There has been high and increasing use and misuse of these medications with inadequate explanation. (4)  Since chronic cannabis use can result in similar cognitive effects as ADHD 5–7, we wondered if more stimulants were prescribed for what appeared to be ADHD but was a consequence of chronic cannabis use. In other words, has the legalization of cannabis contributed to this inadequately explained increase in stimulant use? A recent study by our lab group that looked at the slopes of stimulant distribution rates over time -- before and after medical cannabis legalization -- did not support this.(8) Given the prevalence and increasing legalization of recreational cannabis, we wanted to determine how slopes of stimulant distribution rates compared before and after recreational cannabis legalization. (more…)
Author Interviews, Cannabis, Pharmacology, Tobacco Research / 08.03.2023

MedicalResearch.com Interview with: Philip Lazarus, PhD Boeing Distinguished Professor, Pharmaceutical Sciences Professor, Dept of Pharmaceutical Sciences College of Pharmacy and Pharmaceutical Sciences Washington State University Spokane, WA 99210   MedicalResearch.com: What is the background for this study? Response: Smoking and tobacco use remains a major health issue. Smokers use cigarette over the course of the day because the levels of nicotine, the addictive agent in cigarettes and other forms of tobacco, dimmish with time in the bloodstream due to the breakdown of nicotine by enzymes in the body. By inhibiting the breakdown of nicotine in smokers, one would expect that the levels of nicotine would remain higher after smoking a single cigarette, and that these individuals may not require lighting up another cigarette so quickly, reducing the number of cigarettes smoked over the course of a day. This could have a profound effect on reducing the overall harm incurred from smoking or from using other forms of tobacco. In a single previous study, smokers who used a CBD inhaler exhibited a 40% reduction in cigarette use. In addition, while cannabis users are often smokers, previous studies have indicated that they smoke less cigarettes than non-cannabis-using cigarette smokers. In previous studies published in 2021, we found that major cannabinoids present in cannabis like THC and CBD inhibit major metabolizing enzymes in our body, including several that are important in drug metabolism. We hypothesized that CBD and its major active metabolite, 7-hydroxy (OH)-CBD, may also be inhibiting one or more of the enzymes important in the metabolism (or breakdown) of nicotine. (more…)
Annals Internal Medicine, Author Interviews, Cannabis, Yale / 19.03.2020

MedicalResearch.com Interview with: Joshua D. Wallach, MS, PhD Assistant Professor of Epidemiology (Environmental Health Sciences) Yale School of Public Health New Haven, CT MedicalResearch.com: What is the background for this study? Response: Over the past few years, there has been growing interest in the potential health benefits of cannabidiol (CBD), a chemical compound in cannabis. Although only one CBD-derived prescription drug has been approved by the US Food and Drug Administration (FDA) for the treatment of epilepsy, I recently started seeing products containing CBD advertised and sold across the US (e.g. CBD in foods, beverages, dietary supplements, and cosmetics). I noticed that many of these products were being marketed with unproven claims to prevent, cure, and treat various conditions, and became interested in learning more about the research supporting the use of CBD, the potential for misleading claims, and impact that the CBD-industry may be having on research that is being generated and disseminated to the public. Research funding sources and other author conflicts of interests (e.g. consulting fees, honoraria, travel expenses) can influence the way that research is designed, conducted, and reported. Previous studies have consistently demonstrated associations between authors' conflicts of interest and proindustry conclusions in clinical research. Given the growing number of companies invested in CBD's commercial success, we decided to analyze the disclosed funding sources, conflicts of interest statements, author employment details, and CBD-related conclusions in a large sample of published articles on the characteristics, use, and therapeutic effects of cannabidiol. (more…)
Author Interviews, Cannabis, JAMA, UCSD / 23.10.2019

MedicalResearch.com Interview with: John W. Ayers, PhD, MA Vice Chief of Innovation | Assoc. Professor Div. Infectious Disease & Global Public Health University of California San Diego MedicalResearch.com: What is the background for this study? Response: Touted as a “cure all,” researchers have documented unfounded claims that  cannabidiol (CBD) treats acne, anxiety, opioid addiction, pain, and menstrual problems. You can buy CBD droplets, massage oils, CBD gummies, or even ice cream. But public health leaders have been mostly silent on the subject because they lacked data that demonstrates just how popular CBD is and the future trajectory might be. To fill this data-gap we analyzed Google search queries that mentioned “CBD” or “cannabidiol” emerging from the United States from January 2004 through April 2019 and forecasted searches through December 2019. Rather than relying on self reports, where some might not be willing to discuss CBD openly, our strategy allowed us to directly observed millions of instances of people seeking out information or even shopping for CBD online. (more…)
Author Interviews, Cannabis / 31.08.2019

MedicalResearch.com Interview with: Angela Birnbaum, Ph.D., FAES Professor, Director of Graduate Studies Experimental and Clinical Pharmacology College of Pharmacy University of Minnesota  MedicalResearch.com: What is the background for this study? Response: Little was known about the effect food has on the amount of cannabidiol (CBD) that is actually absorbed into the body. Because of various state laws, CBD preparations vary from state to state. In Minnesota, however, the law only allows pure forms of cannabidiol providing a consistent supply of product including a purified CBD capsule formulation. Due to its pharmacological properties a low amount of a CBD dose reaches the blood stream and the effect of food had not been well described. Our study was done to determine the amount of cannabidiol that is absorbed with food as compared to an empty stomach at doses used in epilepsy patients, which can be higher than the dose often used for other conditions.   (more…)
Author Interviews, Cancer Research, Cannabis, End of Life Care, NYU / 28.03.2019

MedicalResearch.com Interview with: Arum Kim, MD Assistant Professor Medicine and Rehabilitation Medicine NYU School of Medicine Director of the Supportive Oncology Program Perlmutter Cancer Center MedicalResearch.com: What is the background for this study?   Response: There is increasing interest in medical marijuana and its applications for patients with cancers. Despite increasing access, little is known regarding doses of cannabinoids - specifically delta-8-tetrahydrocannabinol (delta-8-THC)  and cannabidiol (CBD), methods of drug delivery, and differences in patterns of use between cancer and non-cancer patients. (more…)
Author Interviews, Cannabis / 25.10.2018

MedicalResearch.com Interview with: Jonathan Rothbard, MA, PhD Steinman Lab Stanford Medicine Co-founder Gold Bee – Pharmaceutical Grade CBD Products MedicalResearch.com: What is the background for this new company? How did Katexco get its name? Response: Researchers with Stanford University, Jonathan Rothbard and Lawrence Steinman, formed Katexco Pharmaceuticals. Katexco will focus on developing oral therapies for inflammatory diseases based on cannabis and nicotine receptors. Katexco will work to develop the first drug to focus on a key receptor on immune cells that are involved in inflammatory disease. The first primary target indications include gastrointestinal disorders like Crohn’s disease, gout and multiple sclerosis. Katexco is from the Greek word to restrain or regulate, and we are trying to restrain the immune system in inflammatory disease. We produce what Observer.com has ranked the #1 CBD oil for pain. In fact, our CBD oil is the best CBD oil for pain according to more than 300 independently verified reviews from consumers on TrustSpot. (more…)