MedicalResearch.com: Would you briefly explain what is meant by autoimmune disorders?
Response: Autoimmune disease is a broad category of related diseases which share both genetic and mechanistic properties. They occur when the person’s immune system attacks the body’s own cell, and tissue. The immune system goes awry and mistakenly attacks the tissues and organs it was designed to protect. Normally the immune system protects the It does this by body by responding to invading microorganisms, such as bacteria, and viruses. Producing antibodies which are special proteins that recognize and destroy the invaders. Autoimmune diseases occur when autoantibodies attack the body’s own cells, tissue and organs. Continue reading →
Andrea L. Roberts, MPH, PhD
Research Associate, Department of Social and Behavioral Sciences
Harvard T.H. Chan School of Public Health
MedicalResearch.com: What is the background for this study?
Response: There is some evidence that depression may increase risk of autoimmune diseases. For example, among people with autoimmune diseases, more people have depression than in the general population. Also, people who have autoimmune diseases who also have depression have more severe disease symptoms.
Daniel J. Wallace M.D., FACP, MACR
Associate Director, Rheumatology Fellowship Program
Board of Governors, Cedars-Sinai Medical Center
Professor of Medicine, Cedars-Sinai Medical Center
David Geffen School of Medicine Center at UCLA
In affiliation with Attune Health
Beverly Hills, Ca 90211
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: This is the first positive study of systemic lupus erythematosus (SLE) using baricitinib, a small oral molecule that blocks the JAK system.
The human kinome consists of 500 genes and helps regulate cell surface receptor interaction. While agents that inhibit certain pathways are approved for rheumatoid arthritis and certain malignancies, this is the first study of its kind in SLE.
MedicalResearch.com Interview with: Dr. Jinoos Yazdany MD, MPH
Assistant Professor in Residence
UCSF School of Medicine
MedicalResearch.com: What are the main findings of the study?
Answer: For almost all of the drugs we examined, we found that less than half of patients adhered to treatment. For some drugs, less than one-third of individuals were adherent. The average medication possession ratios were low across all drugs.
We found that several factors played an important part in adherence. Younger individuals were less likely to adhere to treatment for several drugs, and we also found racial/ethnic differences, with Black, Hispanic and Native populations having lower adherence. We also found geographic variation in adherence, with individuals in the Northeast being the most likely to adhere to treatment.