GERD Associated With Increased Risk of Malignancy of the Upper Aerodigestive Tract Interview with:

Dr. Edward D. McCoul, MD, MPH Ochsner Medical Center

Dr. McCoul

Dr. Edward D. McCoul, MD, MPH
Ochsner Medical Center What is the background for this study? What are the main findings?

Response: Population-level data suggests a link between gastroesophageal reflux disease and cancer of the throat and sinuses in adults over 65 years of age.  T

he strength of association between reflux and cancer is strongest for anatomic sites closest to the esophagus, where acid and other stomach contents may have the greatest exposure. What should clinicians and patients take away from your report?

Response: It is important to point out that a causative link cannot be established from this type of data.

It is unclear what effect acid exposure may have on tumor development, although chronic inflammation is a possibility. What recommendations do you have for future research as a result of this study?

Response: Further research should focus on assessing these associations in a younger population and investigating mechanisms of causation. Thank you for your contribution to the community.


Charles A. Riley, Eric L. Wu, Mei-Chin Hsieh, Michael J. Marino, Xiao-Cheng Wu, Edward D. McCoul. Association of Gastroesophageal Reflux With Malignancy of the Upper Aerodigestive Tract in Elderly Patients. JAMA Otolaryngol Head Neck Surg. Published online December 21, 2017. doi:10.1001/jamaoto.2017.2561

Note: Content is Not intended as medical advice. Please consult your health care provider regarding your specific medical condition and questions.


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Last Updated on December 21, 2017 by Marie Benz MD FAAD