MedicalResearch.com Interview with:Stephanie Faubion, M.D
Director of the Women’s Health Clinic
Mayo Clinic in Rochester
Medical Research: What are the main findings of the study?Dr. Faubion:In this study that included over 1800 women, we found that caffeine intake was associated with more bothersome hot flashes and night sweats in postmenopausal women.
MedicalResearch.com Interview with:Dr. Frank B. Hu MD MPH PhD
Professor of Nutrition and Epidemiology
From the Departments of Nutrition and Epidemiology
Harvard School of Public Health, Boston, MA
MedicalResearch.com: What are the main findings of the study?Dr. Hu: We found that people who increased the amount of coffee they drank each day by more than one cup over a four-year period had a 11% lower risk for type 2 diabetes than those who made no changes to their coffee consumption, but those who decreased their coffee consumption by more than a cup per day increased their type 2 diabetes risk by 17%.
MedicalResearch.com Interview with: Prof. Dr. Christa E. Müller
University of Bonn Pharmaceutical Institute Pharmaceutical
Chemistry I An der Immenburg 4 D-53121 Bonn (Endenich) Germany
MedicalResearch.com: What are the main findings of the study?Prof. Dr. Christa E. Müller: Genetically altered mice which show an aggregation of Tau protein and many symptoms of Alzheimer's Disease which progressively worsen with time was used.
Caffeine was given to one group of mice at an early stage, when the symptoms were still moderate.
The caffeine-treated mice showed better memory and less inflammation and brain damages in comparison to the non-treated control mice. This means that caffeine protected the mice to some extent. The side effects were moderate.
MedicalResearch.com Interview with: Woon-Puay Koh (Associate Professor)
Office of Clinical Sciences
Duke-NUS Graduate Medical School Singapore
8 College Road Level 4 | Singapore 169857
MedicalResearch.com: What are the main findings of the study?Answer:The main finding is that coffee intake was associated with a lower risk of death from cirrhosis, specifically for non-viral hepatitis related cirrhosis. Subjects who drank two or more cups per day had a 66% reduction in mortality risk, compared to non-daily coffee drinkers. However, coffee intake was not associated with viral hepatitis B related cirrhosis mortality.
MedicalResearch.com Interview with:Masato Tsutsui, MD, PhD, FAHA
Professor and Chairman
Department of Pharmacology
Graduate School of Medicine
University of the Ryukyus
Okinawa 903-0215, Japan
MedicalResearch.com: What are the main findings of the study?Dr. Tsutsui: A recent large prospective study reported that coffee consumption is associated with reduced mortality for cardiovascular disease (NEJM 2012). However, its precise mechanisms remain to be clarified. Our double-blind, placebo-controlled, crossover study demonstrated, for the first time, that caffeine contained in a cup of coffee ameliorates microvascular endothelial function in healthy individuals. These findings may explain, at least in part, the association of coffee consumption with reduced mortality for cardiovascular disease.
MedicalResearch.com Interview with:Janet L. Stanford, MPH, PhD Full Member, Research Professor
Co-Head, Program in Prostate Cancer Research
Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N. M4-B874
Seattle, WA 98109-1024
MedicalResearch.com: What are the main findings of the study?Dr. Stanford: The main finding from our research is that one or more cups of coffee per day is associated with a 56% to 59% reduction in the risk of prostate cancer recurrence or progression in men diagnosed with this common disease. In our cohort of prostate cancer patients, 61% reported drinking at least one cup of coffee per day, with 14% reporting drinking 4 or more cups per day. The lower risk for prostate cancer recurrence/progression observed in coffee drinkers, however, was seen even for those who consumed only one cup per day, suggesting that even modest intake of coffee may offer health benefits for prostate cancer patients.
MedicalResearch.com Interview with:Xuemei Sui, MD, MPH, PhD
Department of Exercise Science
Arnold School of Public Health
University of South Carolina
921 Assembly Street Room 226
Columbia, SC 29208
MedicalResearch.com: What are the main findings of the study?Answer: Coffee intake was a risk factor with higher mortality in men, but not in women. Men who drank more than 28 cups of coffee weekly had a 21% higher risk of dying when comparing with their non-coffee-consuming peers. In addition, younger men (age<55 years) who drank more than 28 cups of coffee weekly had a 56% increase in mortality from all-cause and younger women had a greater than 2-fold higher risk of all-cause mortality than those who did not drink coffee.
MedicalResearch.com Interview with:
Helena Hallström Ph.D., M.Sc. (Toxicology)
Department of Surgical Sciences, Section of Orthopedics
Uppsala University, Uppsala, Sweden and
Risk and Benefit Assessment Department National Food Agency, Uppsala, Sweden.
MedicalResearch.com: What are the main findings of the study?Answer: The aim of the study was to investigate whether high consumption of coffee is associated with osteoporosis and development of osteoporotic fractures, since results from previous fracture studies regarding potential associations between coffee drinking and fracture risk are inconsistent. The longitudinal population-based Swedish Mammography Cohort, including 61,433 women born between 1914 and 1948, was followed from 1987 through 2008. Coffee consumption was assessed with repeated food frequency questionnaires. During follow-up, 14,738 women experienced any type of fracture and of these 3,871 had a hip fracture. In a sub-cohort (n=5,022), bone density was measured and osteoporosis was determined (n=1,012). There was no evidence of a higher rate of any fracture or hip fracture with increasing coffee consumption. However, a high coffee intake (≥4 cups) in comparison with a low intake (<1 cup) was associated with a 2-4% reduction in bone mineral density (BMD), depending on site (p<0.001), but the odds ratio of osteoporosis was only 1.28 (95% confidence interval: 0.88, 1.87). Thus, high coffee consumption was associated with a small reduction in bone density that did not translate into an increased risk of fracture.
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