“Rory’s Regulations” Improves Pediatric Sepsis Care

MedicalResearch.com Interview with:

Idris V.R. Evans, M.D.,MA Assistant Professor Department of Critical Care Medicine University of Pittsburgh

Dr. Evans

Idris V.R. Evans, M.D.,MA
Assistant Professor
Department of Critical Care Medicine
University of Pittsburgh

MedicalResearch.com: What is the background for this study? What are the main findings?

Response: New York State issued a state-wide mandate in 2013 for all hospitals to develop protocols for sepsis recognition and treatment. This mandate was called “Rory’s Regulations” in honor of Rory Staunton, a boy who died from sepsis in 2012.

Pediatric protocols involved a bundle of care that included blood cultures, antibiotics, and an intravenous fluid bolus within 1–hour. We analyzed data collected by the NYS Department of Health on 1,179 patients from 54 hospitals and found that the completion of the pediatric bundle within 1 hour was associated with a 40% decrease in the odds of mortality. 

MedicalResearch.com: What should readers take away from your report?

Response: That completing the entire pediatric sepsis protocol within 1 hour is associated with improved survival. 

MedicalResearch.com: What recommendations do you have for future research as a result of this work? 

Response: The mechanism of benefit from the protocol completion requires further study. Is it a combination of physiologic benefits from each individual component that reduces mortality? Or does the completion of the bundle within 1–hour represent heightened awareness by the care team? Or something else?

I have no disclosures.


Evans IVR, Phillips GS, Alpern ER, et al. Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis. JAMA. 2018;320(4):358–367. doi:10.1001/jama.2018.9071

Jul 25, 2018 @ 11:04 am




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