Yun-Han Wang PhD Student Karolinska Institute

Proton-Pump Inhibitors: Small Increased Risk of Fractures in Children

Yun-Han Wang PhD Student Karolinska Institute

Yun-Han Wang Interview with:
Yun-Han Wang, PhD Student

Karolinska Institute What is the background for this study?

Response: Proton pump inhibitor (PPI) use has been linked to increased risk of fracture in adults. Despite an increasing trend in prescription of PPIs in children, there is scarce evidence regarding this safety concern in pediatric patients. What are the main findings?

Response: Our findings suggested that PPI use is associated with a small increased risk of fracture in children. The association was driven by fracture of upper limb, lower limb, and other sites; appeared to be mainly restricted to children aged 6 and older; and seemed to be somewhat more pronounced with longer cumulative duration of PPI use. What should readers take away from your report?

Response: Risk of fracture should be taken into account when weighing the benefits and risks of PPI treatment in children.

No disclosures 


Wang Y, Wintzell V, Ludvigsson JF, Svanström H, Pasternak B. Association Between Proton Pump Inhibitor Use and Risk of Fracture in Children. JAMA Pediatr. Published online March 16, 2020. doi:10.1001/jamapediatrics.2020.0007



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Last Updated on March 17, 2020 by Marie Benz MD FAAD