MedicalResearch.com Interview with:Yanzhuang Wang, PhD
Associate professor
Dept. of Molecular, Cellular and Developmental Biology and Dept. of Neurology University of Michigan
Ann Arbor, MI 48109-1048
MedicalResearch.com: What are the main findings of the study?Dr. Wang: We learned how to repair a cellular structure called the Golgi apparatus that is broken in Alzheimer’s disease. This helps us understand how to reduce the formation of the toxic plaques that kill cells in the brain of Alzheimer's patients. The formation of amyloid plaques is a hallmark of Alzheimer’s disease; but exactly how much the plaques contribute to the disease is still not known. Our study found that the broken Golgi in the disease may be a major source of the toxicity of amyloid plaques. We showed in this study that repairing the Golgi can reduce the formation of the toxic plaques and thus may delay the disease development.
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MedicalResearch.com Interview with:Dr. Victor W. Henderson MD
Professor of Health Research and Policy and of Neurology and Neurological Sciences
Stanford University, Stanford, CA 94305
MedicalResearch.com: What are the main findings of the study?Dr. Henderson: Estrogen or hormone therapy effects on some health outcomes differ by age, harmful at one age and beneficial at another.
This difference is sometimes referred to as the “critical window” or “timing” theory. It is controversial whether the so-called critical-window applies to memory or other cognitive skills.
In assessing the critical window hypothesis, we found that the relation between blood levels of estrogen and memory or reasoning skills is the same in younger postmenopausal women as in older postmenopausal women. Essentially, there is no association at either age.
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MedicalResearch.com Interview with:Agnieszka Anna Tymula
Lecturer (Assistant Professor)
School of Economics
The University of Sydney
NSW 2006, Australia
MedicalResearch.com: What are the main findings of the study?
Answer: We found that individual risk preferences as well as consistency and rationality in choice change with age. Just like cognitive abilities, the ability to make consistent and rational decisions considerably declines in older adulthood. Tolerance to risk in the domain of gains follows an inverted U-shaped pattern along the life span, with older adults (65+ y. o.) and adolescents being more risk averse than young or midlife adults. Interestingly, in the domain of losses, older adults are willing to accept significantly more risks than adolescents, young and midlife adults.
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MedicalResearch.com Interview with Frederic D. Bushman, Ph.D.
Professor, Department of Microbiology
Department of Microbiology
Perelman School of Medicine
University of Pennsylvania
426A Johnson Pavilion 3610 Hamilton Walk
Philadelphia, PA 19104
MedicalResearch.com: What are the main findings of the study?Dr. Bushman: Viral populations in the human gut are huge, and some of the viruses change rapidly over time.
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MedicalResearch.com eInterview with Dr. Mathieu Lupien PhDPrincess Margaret Cancer Centre, University Health Network
Ontario Cancer Institute (OCI)
Assistant Professor
Department of Medical Biophysics
University of Toronto
MedicalResearch.com: What are the main findings of the study?Dr. Lupien: Approximately 50% of breast cancer patients fail to respond to the standard of care based on endocrine (hormonal) therapy. Our research identifies a mechanism that accounts for this resistance. Drugs against this mechanism are already tested for other diseases. Hence, our discovery should rapidly help reposition these drugs against endocrine therapy resistant breast cancer.
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MedicalResearch.com Interview with Karl K. Szpunar PhD
Department of Psychology,
Harvard University, Cambridge, MA 02138
MedicalResearch.com: What are the main findings of the study?Dr. Szpunar: The results of our experiments demonstrate that students can have difficulty paying attention to online lectures, and that including brief quizzes during lectures can help to alleviate this problem. Specifically, we found that students who were tested throughout a 21-minute long Statistics lecture were half as likely to mind wander during the lecture, three times as likely to take additional notes, and much better able to retain the contents of the lecture at a later time.
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MedicalResearch.com Author Interview: Prof. Eytan DomanyDepartment of Physics of Complex Systems and Department of Biological Regulation, Weizmann Institute of Science, Rehovot, 76100, Israel
MedicalResearch.com: What are the main findings of the study?Prof. Domany: The findings are two-fold: methodological and clinical. A novel method was introduced for personalized analysis of cancer, and was applied on large colon cancer and glioblastoma datasets.
The method uses high throughput (gene expression) data to infer a pathway deregulation score (PDS) for individual tumors, for hundreds of pathways and biological processes. The method is knowledge-based in that it uses well known information about the assignment of genes to biologically relevant pathways. No detailed knowledge of the underlying networks of interactions and activations is necessary. Each tumor is represented by a few hundred of these PDSs, and further analysis uses this representation.
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