Menopause
04 Jan Osteoporosis: Improving Bone Mineral Density Postmenopause with Monoclonal Antibody Romosozumab
MedicalResearch.com Interview with
Michael McClung, MD
Founding Director, Oregon Osteoporosis Center
5050 NE Hoyt Street, Suite 626
Portland, OR 97213
MedicalResearch.com: What are the main findings of the study?
Dr. McClung: In this Phase 2 trial, each of five romosozumab dose regimens significantly increased BMD compared with pooled placebo groups at the lumbar spine, total hip and femoral neck regions (all p<0.001). The largest increases were observed with the romosozumab 210 mg once-monthly dose, with mean increases, compared with baseline, of 11.3 percent at the lumbar spine, 4.1 percent at the total hip and 3.7 percent at the femoral neck.
06 Dec Sugar-Sweetened Beverages and Endometrial Cancer
MedicalResearch.com Interview with:
Maki Inoue-Choi, PhD, MS, RD
Division of Cancer Epidemiology and Genetics, National Cancer Institute
National Institute on Minority Health and Health Disparities, NIH
Rockville, MD 20850
MedicalResearch.com: What are the main findings of the study?
Answer: In our study, postmenopausal women who reported higher consumption of sugar-sweetened beverages were more likely to develop estrogen-dependent type I endometrial cancer, the most common type of this cancer.
28 Nov Menopause: Effects of Sex Hormones on Cognition and Mood
MedicalResearch.com Interview with:
Dr. Victor W. Henderson MD
Professor of Health Research and Policy and of Neurology and Neurological Sciences
Stanford University, Stanford, CA 94305
MedicalResearch.com: What are the main findings of the study?
Dr. Henderson: Estrogen or hormone therapy effects on some health outcomes differ by age, harmful at one age and beneficial at another.
This difference is sometimes referred to as the “critical window” or “timing” theory. It is controversial whether the so-called critical-window applies to memory or other cognitive skills.
In assessing the critical window hypothesis, we found that the relation between blood levels of estrogen and memory or reasoning skills is the same in younger postmenopausal women as in older postmenopausal women. Essentially, there is no association at either age.
04 Nov Hot Flashes: Study of Local Anesthetic Nerve Block
MedicalResearch.com Interview with:
David Walega, MD
Chief of the Division of Pain Medicine
Northwestern Memorial Hospital and
Northwestern University Feinberg School of Medicine.
MedicalResearch.com: What are the main findings of the study?
Dr. Walega: Patients who underwent a single stellate ganglion injection with a local anesthetic had a 50% decrease in moderate -to- very severe hot flashes and this effect appeared to last thru the 6 month duration of the study; the placebo or "sham control" group had injections of saline and they did not demonstrate long-term improvements in hot flash symptoms
07 Oct Menopausal Hormone Therapy and Health Outcomes
Posted at 00:37h
in Author Interviews, Brigham & Women's - Harvard, Hormone Therapy, JAMA, Medical Research Centers, Menopause
MedicalResearch.com Interview with: JoAnn E. Manson, MD, DrPH Chief, Division of Preventive Medicine Brigham and Women's Hospital Professor of Medicine and the Michael and Lee Bell Professor of Women's Health Harvard Medical School Boston , Massachusetts 02215 WHI investigators publish most comprehensive report to date on the two Hormone Therapy Trials and extend follow-up to 13 years:...
03 Oct Yoga and Effect on Menopause Symptoms
MedicalResearch.com Interview with: Katherine Newton, PhD Senior Investigator at Group Health Research Institute in Seattle MedicalResearch.com: What are the main findings of the study? Answer: We found that when women took a 12-week yoga class and practiced yoga at home, they had significantly less insomnia than did women who did not. This was the only statistically significant finding in this MsFLASH (Menopause Strategies: Finding Lasting Answers for Symptoms and Health) Network randomized controlled trial. We also found that being in the yoga class did not decrease the number of hot flashes or night sweats. Yoga was linked to better sleep quality and less depression—but these effects were not statistically significant. In separate papers, published slightly earlier, our MsFLASH group reported that a non-yoga exercise program seemed linked to slightly improved sleep and less insomnia and depression—but these effects were not statistically significant. And an omega-3 (fish oil) supplement was not linked to any improvement in hot flashes, night sweats, sleep, or mood.03 Sep Postmenopausal Women: Impact Brisk Walking
MedicalResearch.com Interview with: Pascale Mauriège, PhD, Division of Kinesiology PEPS, Room 2148, Laval University, Québec, Canada G1K 7P4 MedicalResearch.com: What are the main findings of the study? Answer: 1) The impact of a 4-month brisk walking program (3 sessions/week of 45-min walking at 60% of heart rate reserve) on postmenopausal moderately obese (BMI=29-35 kg/m2) women’s perceived health, and more particularly the perceived ideal weight and stress level. 2) The existence of a relationship between improvements in perceived ideal weight and fat mass reduction in the walking group. 3) The lack of non respondents to our novel self-administered Short Perceived Health Questionnaire (SPHQ) that was completed within 2-3 min by all participant. 4) The good reproductibility for five of six items of the SHPQ, and the validation of three questions against generic tools.26 Jul Should the Ovaries be Removed at Time of Hysterectomy for Benign Disease?
MedicalResearch.com Interview with: Catherine A. Matthews, MD Associate Professor and Division Chief Urogynecology and Reconstructive Pelvic Surgery University of North Carolina, Chapel Hill MedicalResearch.com: What are the main findings of the study? Dr. Matthews: Women under 50 should try and preserve their ovaries at the time of hysterectomy for benign disease; however, women over 50 should consider elective ovarian removal as a way to reduce ovarian cancer. There is no adverse impact on cardiovascular, bone or sexual health in women over 50 who elect ovarian removal.28 Mar Adipocyte Fatty Acid storage factors enhance subcutaneous fat storage in postmenopausal women
MedicalResearch.com Interview with
Dr. Sylvia Santosa, PhD
Department of Exercise Science
Concordia University
Department of Exercise Science
Montreal, Quebec, Canada H4B 1R6
MedicalResearch.com: What are the main findings of the study?
Dr. Santosa: Our results show that postmenopausal women burn less fat making more available to be stored. Our results also suggest that greater fat storage in postmenopausal women are likely to be attributed to changes in the pathways our fat cells use to store fat. We found that some of the proteins that help our fat cells store fat were more active and this greater activity corresponded with the amount of fat stored from our circulation.
05 Oct Estrogen Effects on Metabolism & Weight Gain in Women Studied
It's no secret that women often gain weight as they get older. The sex hormone estrogen has an important, if underappreciated, role to play in those burgeoning waistlines. Now, researchers reporting in the October Cell Metabolism, a Cell Press publication, have traced those hormonal effects on metabolism to different parts of...