Author Interviews, Infections / 12.03.2026
Vanderbilt Physician Discusses Newly Recognized and Contagious Human Metapneumovirus
MedicalResearch.com Interview with:
[caption id="attachment_72776" align="alignleft" width="148"]
Dr. Schaffner[/caption]
Dr. William Schaffner M.D.
Professor of Medicine
Preventive Medicine, Health Policy
Division of Infectious Diseases
Vanderbilt University School of Medicine
Interview arranged with the assistance of the Infectious Disease Society of America.
MedicalResearch.com: What are the symptoms of HMPV? How is it transmitted? Are some individuals more susceptible to infection or more serious disease?
Response: Human metapneumovirus (HMPV) is a seasonal respiratory virus that has a worldwide distribution, causing late winter/early spring outbreaks in temperate zones. It cocirculates with other seasonal respiratory viruses including influenza, COVID, and RSV. Virtually all children have experienced infection by age 5; persons experience HMPV reinfections throughout life. The virus is transmitted through close personal contact, most efficiently indoors. Infection with HMPV can produce a spectrum of clinical symptoms ranging from a common cold to acute respiratory distress. Persons at increased risk of severe disease include older persons and those with chronic medical conditions.
Dr. Schaffner[/caption]
Dr. William Schaffner M.D.
Professor of Medicine
Preventive Medicine, Health Policy
Division of Infectious Diseases
Vanderbilt University School of Medicine
Interview arranged with the assistance of the Infectious Disease Society of America.
MedicalResearch.com: What are the symptoms of HMPV? How is it transmitted? Are some individuals more susceptible to infection or more serious disease?
Response: Human metapneumovirus (HMPV) is a seasonal respiratory virus that has a worldwide distribution, causing late winter/early spring outbreaks in temperate zones. It cocirculates with other seasonal respiratory viruses including influenza, COVID, and RSV. Virtually all children have experienced infection by age 5; persons experience HMPV reinfections throughout life. The virus is transmitted through close personal contact, most efficiently indoors. Infection with HMPV can produce a spectrum of clinical symptoms ranging from a common cold to acute respiratory distress. Persons at increased risk of severe disease include older persons and those with chronic medical conditions.
Dr. Wallis[/caption]
Christopher Wallis, MD, PhD
Assistant Professor of Urology
Department of Surgery
University of Toronto and Urologic Oncologist
Mount Sinai Hospital
MedicalResearch.com: Could you give a little context - what was the question you were looking at?
Dr. Mosley[/caption]
Jonathan Mosley, MD, PhD
Associate Professor
Division of Clinical Pharmacology
Departments of Internal Medicine and Biomedical Informatics
Vanderbilt University Medical Center
MedicalResearch.com: What is the background for this study?
Response: Prostate cancer is an important source of morbidity and mortality among men. Earlier detection of disease is essential to reduce these adverse outcomes. Prostate cancer is heritable, and many single nucleotide polymorphisms (SNPs) associated with disease risk have been identified. Thus, there is considerable interest in using tools such as polygenic risk scores, which measure the burden of genetic risk variants an individual carries, to identify men at elevated risk of disease.
Dr. Jeffrey Smith[/caption]
Jeffrey R. Smith, MD PhD
Department of Medicine, Division of Genetic Medicine
Vanderbilt-Ingram Cancer Center, and Vanderbilt Genetics Institute
Vanderbilt University Medical Center
Medical Research Service
Tennessee Valley Healthcare System, Veterans Administration
Nashville, TN
MedicalResearch.com: What is the background for this study?
Response: Roughly 20% of men with prostate cancer have a family history of the disease, and 5% meet criteria for hereditary prostate cancer. Although prostate cancer has the greatest heritability of all common cancers (twice that of breast cancer), extensive heterogeneity of its inherited causes has presented a considerable obstacle for traditional pedigree-based genetic investigative approaches. Inherited causes across, as well as within families are diverse.
This study introduced a new familial case-control study design that uses extent of family history as a proxy for genetic burden. It compared a large number of men with prostate cancer, each from a separate family with a strong history of the disease, to screened men with no personal or family history. The study comprehensively deconstructs how the 8q24 chromosomal region impacts risk of hereditary prostate cancer, introducing several new analytical approaches. The locus had been known to alter risk of prostate, breast, colon, ovarian, and numerous additional cancers.
Kathryn M. Edwards, M.D.
Sarah H. Sell and Cornelius Vanderbilt Chair in Pediatrics
Professor of Pediatrics
Vanderbilt University School of Medicine
Dr. Edwards discusses the statement from the Infectious Diseases Society of America (IDSA) regarding the Centers for Disease Control and Prevention’s new data on child vaccine rates across the United States.
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: To monitor the uptake of vaccines the CDC conducts a National Immunization Survey each year. This survey is conducted by random-digit dialing (cell phones or landlines) of parents and guardians of children 19-35 months of age. The interviewers ask the families who provides the vaccines for their children and if these providers can be contacted to inquire about the immunizations received. The overall response rate to the telephone survey was 26% and immunization records were provided on 54% of the children where permission was granted. Overall 15, 333 children had their immunization records reviewed.
When comparing immunization rates for 2017 and 2016, the last two years of the study, several new findings were discovered.
First the overall coverage rate for 3 doses of polio vaccine, one dose of MMR, 3 doses of Hepatitis b, and 1 dose of chickenpox vaccine was 90%, a high rate of coverage. Children were less likely to be up to date on the hepatitis A vaccine (70%) and rotavirus vaccine (73%). Coverage was lower for children living in rural areas when compared with urban areas and children living in rural areas had higher percentages of no vaccine receipt at all (1.9%) compared with those living in urban areas (1%).
There were more uninsured children in 2017 at 2.8% and these children had lower immunization rates. In fact 7.1% of the children with no insurance were totally unimmunized when compared with 0.8% unimmunized in those with private insurance. Vaccine coverage varies by state and by vaccine.