Author Interviews, Breast Cancer, Johns Hopkins, Stem Cells / 13.08.2013

Harvard Stem Cell Institute's Kornelia Polyak, MD, PhD, MedicalResearch.com Interview with: Kornelia Polyak, MD, PhD Professor of Medicine Dana-Farber Cancer Institute Harvard Medical School Boston, MA 02215 MedicalResearch.com: What are the main findings of the study? Dr. Polyak: We found that when comparing normal breast tissue of women who have not had children (nulliparous) and those who had children in their early 20s, the largest changes are in breast epithelial progenitors. The frequency of these cells is lower in parous women (women who had children) and the properties are also altered in a way that they are less likely to proliferate. Women with high risk of breast cancer, such as BRCA1 and BRCA2 mutation carriers, have very high frequency of these cells, and also parous women who did get cancer have more than those who did not. These results indicate that the frequency of these cells may predict breast cancer risk. (more…)
Author Interviews, Breast Cancer, Race/Ethnic Diversity / 07.08.2013

MedicalResearch.com Interview with: Lindsey Enewold PhD, MPH Division of Military Epidemiology and Population Sciences John P. Murtha Cancer Center Walter Reed National Military Medical Center Rockville, Maryland MedicalResearch.com: What are the main findings of the study?
 Answer: With increasing time since breast cancer diagnosis women were less likely to receive surveillance mammography. Minority women were equally or more likely than non-Hispanic white women to receive surveillance mammography within an equal access healthcare system. (more…)
Author Interviews, Breast Cancer, Radiology, Yale / 30.07.2013

MedicalResearch.com Interview with Dr. Brian Haas MD Department of Diagnostic Radiology,Yale University School of Medicine, New Haven, CT Dr. Brian Haas MD Department of Diagnostic Radiology,Yale University School of Medicine, New Haven, CT MedicalResearch.com: What are the main findings of the study? Dr. Haas: We found that tomosynthesis helped to reduce the number of women who undergo a screening mammogram and are called back for additional imaging and testing. Specifically, the greatest reductions in patients being called back were seen in younger patients and those with dense breasts. Tomosynthesis is analogous to a 3D mammogram, and improves contrast of cancers against the background breast parenchyma. (more…)
Author Interviews, Breast Cancer, Cancer Research, Radiology, Yale / 01.07.2013

MedicalResearch.com Interview with: Sarah H. O'Connell M.D. PGY-4 Yale New Haven Hospital Yale School of Medicine Department of Diagnostic Radiology MedicalResearch.com:  What are the main findings of the study? Answer: The purpose of our study was to evaluate the visibility of cancers in women at high-risk for breast cancer on 2D mammography compared to digital breast tomosynthesis. In other words, how would the use of tomosynthesis contribute to cancer visualization in this population  of patients? We evaluated the cancers seen in both high-risk patients, those with a >20% lifetime risk of breast cancer, and intermediate risk  patients, those with a 15-20% lifetime risk of breast cancer, for a total of 56 cancers. We found that 41% (23/56) cancers were better seen on tomosynthesis and 4% (2/56) were only seen on tomosynthesis. The majority of the cancers seen better or only on tomosynthesis  presented as masses rather than as calcifications alone which were better seen on 2D mammography. (more…)
Author Interviews, BMJ, Breast Cancer, Cancer Research, Fish, Nutrition / 28.06.2013

MedicalResearch.com Interview with Duo Li (PhD, MSc, BMed) Co-Editor, Asia Pacific Journal of Clinical Nutrition Associate Editor, Journal of Nutrigenetics & Nutrigenomics Professor of Nutrition Dept. of Food Science & Nutrition Zhejiang University 866 Yu-Hang-Tang Road Hangzhou 310058, China MedicalResearch.com: What are the main findings of the study? Dr. Li: The main finding is that intake marine n-3 polyunsaturated fatty acids (n-3 PUFAs) from both fish and fish oil lower the risk of breast cancer. Women with a high intake of marine n-3 PUFAs had a 14-percent reduction in risk of breast cancer compared with those who had a low intake. Every 0.1 g increase in marine n-3 PUFA per day was linked to a five-percent reduction in breast cancer risk. (more…)
Author Interviews, Breast Cancer, Genetic Research, PNAS / 03.04.2013

MedicalResearch.com eInterview with Dr. Mathieu Lupien PhD Dr. Mathieu Lupien PhD  Princess Margaret Cancer Centre, University Health Network Ontario Cancer Institute (OCI)  Assistant Professor Department of Medical Biophysics University of Toronto Princess Margaret Cancer Centre, University Health Network Ontario Cancer Institute (OCI) Assistant Professor Department of Medical Biophysics University of Toronto MedicalResearch.com: What are the main findings of the study? Dr. Lupien: Approximately 50% of breast cancer patients fail to respond to the standard of care based on endocrine (hormonal) therapy. Our research identifies a mechanism that accounts for this resistance. Drugs against this mechanism are already tested for other diseases. Hence, our discovery should rapidly help reposition these drugs against endocrine therapy resistant breast cancer. (more…)
Author Interviews, Breast Cancer, Cancer Research, Depression, Mental Health Research / 28.03.2013

MedicalResearch.com Interview with Mylin A. Torres, M.D. Assistant Professor Department of Radiation Oncology Emory University School of Medicine Atlanta, GA 30322 MedicalResearch.com: What are the main findings of the study?  Dr. Torres: Radiation treatment for breast cancer is not associated with increased depressive symptoms, but of disease and treatment-related factors, prior chemotherapy treatment is a significant predictor of depression before and after radiation treatment.  Prior chemotherapy treatment was associated with inflammatory mediators, including nuclear factor-kappa B DNA binding, soluble tumor necrosis factor-alpha receptor 2, and interleukin-6, which predicted for depressive symptoms after radiation on univariate analysis. (more…)