04 Aug Columbia University Study Finds Lithium in Tap Water Exceeds Health Screening Levels in Western U.S. Tribal Communities
MedicalResearch.com Interview with:
Ellen B. Bannon, MPH
PhD Student, Department of Environmental Health Sciences
Columbia Mailman School of Public Health
Ellen Bannon[/caption]
MedicalResearch.com: What is the background for this study? What are the main findings?
Ms. Bannon: Lithium is an increasingly important element thanks to its use in rechargeable batteries and the green energy transition. However, we know relatively little about how people are exposed to lithium in their everyday lives. In many areas of the United States, lithium is present in groundwater and drinking water due to natural weathering processes, but few studies have quantified human exposure to lithium. Our study addresses this gap by measuring lithium in household tap water and urine samples from participants in the Strong Heart Family Study across Tribal communities in Arizona, Oklahoma, North Dakota, and South Dakota. This approach parallels earlier work examining other naturally occurring groundwater contaminants — a framework explored in this MedicalResearch.com overview of how naturally occurring contaminants in drinking water affect human health even at low exposure levels.
Our main findings were threefold. First, household drinking water samples frequently exceeded the United States Geological Survey health-based screening level of 10 µg/L, with 100% and 93% of samples exceeding the screening level in Arizona and North Dakota/South Dakota, respectively. Both water and urine lithium levels were highest in Arizona and lowest in Oklahoma. Second, household drinking water is an important contributor to internal lithium exposure — water lithium concentrations were significantly associated with urinary lithium levels and explained approximately 29% of variation in urinary lithium. Finally, urinary lithium levels remained stable between our urine sampling periods (2006–2009 and 2022–2024), suggesting that environmental lithium exposure has remained persistent over time.
Prof. Guohua Li[/caption]
MedicalResearch.com Interview with:
Guohua Li, MD, DrPH
Finster Professor of Epidemiology and Anesthesiology
Columbia University Irving Medical Center
MedicalResearch.com: What is the background for this study? How was the ADHD diagnosis determined?
Response: The reported prevalence of ADHD in children and young adults in the United States has more than doubled since the 1990s because of improved diagnosis. Currently, ADHD affects about 13 percent of children under 18 years of age and eight percent of adults under 45 years of age. Little is known about the prevalence of ADHD in older adults although it is estimated that ADHD symptoms may persist throughout the lifespan in about one-third of children diagnosed with the disorder. Diagnostic criteria for adulthood ADHD include having five or more relevant symptoms, adverse impact on social, academic, and occupational activities, and onset of symptoms before age 12.
In this study, ADHD status is determined based on an affirmative response to the question of whether the participant had ever had ADHD or had ever been told by a doctor or other health professional that he or she had ADHD.
Dr. Stingone[/caption]
Jeanette Stingone PhD
Assistant Professor, Epidemiology
Mailman School of Public Health
Columbia University
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Lead is a well-established neurotoxin, particularly when exposure occurs early in life and in childhood. Associations between elevated blood lead levels and lower scores on tests of neurodevelopment and cognition are seen consistently across studies, even when examining lower levels of exposure.
While reducing exposure to lead is the primary intervention to prevent these adverse outcomes, there aren’t many interventions designed to support the neurodevelopment of children who have been exposed to lead. Some municipalities consider elevated blood lead levels as a criteria for inclusion in Early Intervention programs. Early Intervention programs are mandated under the Individuals with Disabilities Education Act and provide services for children younger than 3 years old with disabilities or developmental delays.
The objective of this study was to compare 3rd grade standardized test scores among children who had elevated blood lead levels early in life to see if children who had received Early Intervention services performed better on these tests than those who did not receive services. Using matching methods and an existing administrative data linkage of children who were born and attended public school in New York City, we observed that children exposed to lead who received Early Intervention services scored higher on standardized tests in both math and English Language arts than children exposed to lead who did not receive services.