JohnsHopkins Tag
26 Apr Dog Walking Sends Thousands to Emergency Rooms Each Year
MedicalResearch.com Interview with: [caption id="attachment_60356" align="alignleft" width="150"]
Ridge Maxson[/caption]
Ridge Maxson
M.D. Candidate, Class of 2024
Johns Hopkins University School of Medicine
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Dog walking is an increasingly popular mode of physical activity for adults in the US, but its injury burden and associated risk factors are not fully understood. This study found that the 3 most common injuries sustained by adult dog walkers in the US were finger fracture, TBI, and shoulder sprain or strain. Dog walking-related injuries sent approximately 423,000 adults to US EDs between 2001 and 2020, with an annual average of more than 21,000 visits. During that 20-year period, the estimated annual injury incidence increased by more than 4-fold. Among injured dog walkers, older adults and women were particularly vulnerable to serious injury, such as fracture and TBI.
26 Mar Biomarker hsTroponin Predictive of Mortality Risk in Older Diabetics
MedicalResearch.com Interview with: [caption id="attachment_53641" align="alignleft" width="150"] Olive Tang[/caption]
Olive Tang, MD/PhD Student
Johns Hopkins School of Medicine
[caption id="attachment_53642" align="alignleft" width="150"]
Dr. Selvin[/caption]
Elizabeth Selvin, PhD, MPH
Professor of Epidemiology & Medicine
Director, Cardiovascular and Clinical Epidemiology
Department of Epidemiology
Welch Center for Prevention, Epidemiology and Clinical Research and the
Johns Hopkins Bloomberg School of Public Health
MedicalResearch.com: What is the background for this study?
Response: The best approach to diabetes management in older adults is unclear. A new blood test called high-sensitivity troponin can detect damage to the heart, even in people without any signs or symptoms of heart disease.
13 Jun Use of AV Grafts Drops in Dialysis Patients, But Still Room For Improvement
MedicalResearch.com Interview with: [caption id="attachment_49763" align="alignleft" width="80"] Dr. Hicks[/caption]
Caitlin W. Hicks, M.D., M.S.
Assistant Professor of Surgery
Recipient of the Department of Surgery
Rothman Early Career Development Award for Surgical Research
Johns Hopkins Medicine
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Arteriovenous fistula are associated with better long-term patency, lower rates of infection, and lower long-term costs compared to arteriovenous graft. As a result, the Fistula First Catheter Last Guidelines recommend placement of an arteriovenous fistula over an AVG whenever possible.
We looked at individual physician utilization of AVF vs AVG for first-time AV access in Medicare beneficiaries. We found that the median physician utilization rate for AVG was only 18%, but that 21% of physicians use AVG in more than 34% of cases, which is above currently recommended practice guidelines.
09 May Novel Lantibiotic Against C. diff Infections May Improve Lipid Profile
Posted at 17:03h
in Author Interviews, C. difficile, Gastrointestinal Disease, Johns Hopkins, Lipids
MedicalResearch.com Interview with:
[caption id="attachment_49043" align="alignleft" width="178"] Dr. Rajesh Kumar NV[/caption]
Rajesh Kumar NV, Ph.D.
Affiliation during the study:
Senior Manager, Human Therapeutics Division,
Intrexon Corporation, Germantown, MD, USA
Current affiliation:
Translational Research Program Manager, Oncology Drug Discovery,
Department of Radiation Oncology and Molecular Radiation Sciences,
Johns Hopkins University School of Medicine
Baltimore, MD,
MedicalResearch.com: What is the background for this study?
Response: Clostridium difficile is a bacterium that can cause symptoms ranging from diarrhea to life-threatening inflammation of the colon. Clostridium difficile infection is the most frequent form of colitis in hospitals and nursing homes and affects millions of patients in the United States and abroad. Clostridium difficile associated disease (CDAD) is a global public health challenge where even mild to moderate infections at times can quickly progress to a fatal disease if not treated promptly.
OG253 is a novel lantibiotic in development for the treatment of CDAD. Lantibiotics are antimicrobial peptides whose chemical structure includes a bridge maintained by the non-canonical amino acid lanthionine. The primary objective of our study was to evaluate the repeated dose toxicokinetics and any possible side effects of OG253 as enteric-coated capsules following daily oral administrations of three different doses (6.75, 27 and 108 mg/day) for a single day or seven consecutive days in both genders of rats.
An enteric-coated capsule of OG253 was formulated in an attempt to circumvent the proteolytic degradation of OG253 in the upper digestive tract and specifically deliver this lantibiotic to the distal portion of the small intestine.
07 May COPD: Aclidinium Bromide (Tudorza Pressair) Has Favorable Safety Profile in Patients with CVD
MedicalResearch.com Interview with: [caption id="attachment_48985" align="alignleft" width="80"] Dr. Wise[/caption]
Robert A. Wise, M.D.
Professor of Medicine
Pulmonary and Critical Care
Johns Hopkins University School of Medicine
Baltimore, MD
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: There has been a lingering controversy about the safety of long-acting anti-muscarinic agents (LAMA) as maintenance treatment for COPD in patients who have increased cardiovascular risk. This study enrolled participants with COPD who also had increased cardiovascular risk or known cardiovascular disease. Participants were randomly treated with either aclidinium bromide (Tudorza Pressair) or placebo.
Over 3 years of follow up there was no increased risk of adverse cardiovascular events. Moreover, the medication had a significant benefit in terms of reducing exacerbations and COPD hospitalizations.